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NCT Number: NCT07386119

Investigation of the Effects of Vestibular Rehabilitation and Dynamic Neuromuscular

This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. Evaluation tools include the Brunnstrom Motor Staging, Fugl-Meyer Upper Extremity Motor Function Scale, Modified Ashworth Scale, Mini-Mental State Examination, Berg Balance Scale, Stroke Impact Scale, and Timed Up and Go test.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Hemiplegia Nervous System Diseases Neurologic Manifestations Paralysis Pathological Conditions, Signs and Symptoms Physiotherapy and Rehabilitation Signs and Symptoms Vestibular Exercises

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Medipol University

Istanbul, Turkey (Türkiye)

About this study

This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. A total of 45 hemiplegic patients will enrolled and randomized into three groups: Conventional Exercise Group (CEG, n = 15), Dynamic Neuromuscular Stabilization Group (DNSG, n = 15), and Vestibular Rehabilitation Group (VRG, n = 15). Each group will be participated in specialized exercise programs twice a week for six weeks. All groups will be underwent assessments before and after treatment. Evaluation tools include the Brunnstrom Motor Staging, Fugl-Meyer Upper Extremity Motor Function Scale, Modified Ashworth Scale, Mini-Mental State Examination, Berg Balance Scale, Stroke Impact Scale, and Timed Up and Go test.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being 18 years of age or older
  • Having experienced at least one stroke and presenting with hemiplegic symptoms
  • Having passed at least one year since the stroke even
  • Scoring at least 24 points on the Mini-Mental State Examination (MMSE)
  • Being able to walk independently for at least 30 meters without assistance
  • Being able to comply with and participate in the exercise program

Exclusion criteria

  • Individuals with chronic pulmonary and/or cardiac diseases
  • Presence of uncontrolled hypertension
  • Conditions accompanied by peripheral nerve injury or lower motor neuron disorders
  • Presence of additional neurological disorders such as ataxia, dyskinesia, or dystonia
  • Severe spasticity, peripheral lesions, pressure ulcers, marked muscle atrophy, obesity, skin irritation, or use of a cardiac pacemaker
  • Presence of vestibular symptoms such as vertigo or dizziness

Treatment and study plan

Conventional Exercise programs

Other

This group participated in Conventional Exercise programs twice a week for six weeks.

Dynamic Neuromuscular Stabilization

Other

This group participated in Dynamic Neuromuscular Stabilization Exercise programs twice a week for six weeks.

Vestibular Rehabilitation Group

Other

This group participated in Vestibular Rehabilitation programs twice a week for six weeks.

Primary outcomes

  1. The Fugl-Meyer Assessment of Upper Extremity

    Time frame: From the beginning of treatment to the end of the 6th week

    It is a standardized, stroke-specific, performance-based outcome measure used in clinical trials to evaluate motor recovery of the upper limb. It assesses movement, coordination, and reflex activity of the shoulder, elbow, forearm, wrist, and hand, providing a quantitative measure of motor impairment and recovery over time. The maximum score for the arm section is 36. During the finger-to-nose test, coordination and speed of movement are evaluated out of 6 points, while tremor, dysmetria, and speed of movement in the upper extremity are also examined in detail.

  2. Modified Ashworth Scale (MAS)

    Time frame: From the beginning of treatment to the end of the 6th week

    It is a widely used clinical outcome measure in clinical trials to assess spasticity by grading the resistance encountered during passive muscle stretching. The joint is passively moved with repetitive and rapid movements, and the joint's resistance to these movements is scored.

  3. Mini-Mental State Examination (MMSE)

    Time frame: From the beginning of treatment to the end of the 6th week

    It is a brief, standardized cognitive screening tool used in clinical trials to assess global cognitive function, including orientation, attention, memory, language, and visuospatial abilities. The total score ranges from 0 to 30, with higher scores indicating better cognitive performance. Scores of 24-30 indicate normal cognition, 18-23 mild cognitive impairment, and ≤17 moderate to severe cognitive impairment.

  4. Berg Balance Scale (BBS)

    Time frame: From the beginning of treatment to the end of the 6th week

    This is a 14-item scale that assesses a patient's ability to maintain balance for a specific period during static and various functional movements. The scoring system ranges from 0 to 4, with 0 meaning "cannot" and 4 meaning "can do independently," and the maximum total score is 56. A total score between 0-20 indicates a high risk of falls; between 21-40 indicates a moderate risk of falls; and between 41-56 indicates a low risk of falls.

  5. Stroke Impact Scale (SIS)

    Time frame: From the beginning of treatment to the end of the 6th week

    It is a stroke-specific, patient-reported outcome measure widely used in clinical trials to evaluate the perceived impact of stroke on multiple domains of health-related quality of life. Based on the obtained score, 0 indicates no recovery, whereas 100 represents complete recovery.

  6. Timed Up and Go (TUG)

    Time frame: From the beginning of treatment to the end of the 6th week

    The test is a simple and widely used functional mobility assessment in clinical trials. It measures the time required for an individual to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. Shorter completion times indicate better functional mobility and balance, and the test is commonly used to assess fall risk and mobility limitations.

Sponsors and collaborators

Lead sponsor

Istanbul Medipol University Hospital

Other

Registry information

Official study title

Investigation of the Effects of Vestibular Rehabilitation and Dynamic Neuromuscular Stabilization Exercises on Balance and Mobility in Patients With Hemiplegia

Acronym: Dynamic

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 4, 2026
Registry last updated
Feb 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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