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OpenTrials
Completed

NCT Number: NCT03606915

Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.

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Key information

Conditions

Pain Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Cheng Kung University

Tainan, 701, Taiwan

About this study

The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • . Patients undergo spinal anesthesia
  • . Over 20 years of age
  • Patients who are competent to understand the study and provide written informed consent.

Exclusion criteria

  • Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis)
  • Refuse participated in this study or pre-existent neurological disease.
  • Patients with advanced tumor staging (stage 3 or 4).

Treatment and study plan

pain evaluation

Behavioral

collect CSF during spinal anesthesia

Primary outcomes

  1. cytokine measurement in cerebrospinal fluid

    Time frame: through study completion, an average of 1 year

    cytokine measurement ( via ELISA) in cerebrospinal fluid

  2. cytokine measurement in blood

    Time frame: through study completion, an average of 1 year

    cytokine measurement (via ELISA) in blood

Sponsors and collaborators

Lead sponsor

National Cheng-Kung University Hospital

Other

Registry information

Important dates

Study start
2015
Primary completion
2019
Study completion
2019
First posted
Jul 31, 2018
Registry last updated
Feb 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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