Investigating STAT3 as a Driver of Pathology in Periodontitis

Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Dentistry, University of Chile

Santiago, Chile

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18-year-old, in good general health, and had no significant medical history.
no history of diabetes or other diseases different than periodontitis.

Exclusion criteria

Pregnancy and lactation
Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.

Treatment and study plan

No intervention

Other

no intervention

Primary outcomes

STAT3 detection in gingival tissues

Time frame: 1 day

Detection of STAT3 in gingival tissues

Sponsors and collaborators

Lead sponsor

University of Chile

Other

Registry information

Official study title

Investigating STAT3 as a Driver of Pathology and Potential Therapeutic Target in Periodontitis

Important dates

Study start: 2019
Primary completion: 2022
Study completion: 2022
First posted: Aug 18, 2022
Registry last updated: Jan 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed