Skip to main content
OpenTrials
Completed

NCT Number: NCT04938414

Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Subarachnoid Hemorrhage, Aneurysmal Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Embolism and Thrombosis Hemorrhage Inflammation Intracranial Hemorrhages Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Subarachnoid Hemorrhage Thrombosis Vascular Diseases

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Second affiliated hosipital of zhejiang univerisity school of medicine

Hangzhou, Zhejiang, 310000, China

About this study

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage (SAH).

1.40 patients with SAH will be included. The CSF will used for ELISA test for inflammatory factors and cogulation factors.

2.CSF obtained from 4 patients with non-neuroloogical disease with 4 addittional SAH patients will be used for Mass Spectrometry

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • SAH patients with modified Fisher Scale 3-4.

Exclusion criteria

  • Patients with history of CNS disease (e.g., stroke, traumatic brain injury, CNS infection) or accompanied by serious comorbidities before SAH onset (e.g., severe coagulation disorders, malignant tumor, uncontrollable heart disease, and hypertension) or other organ dysfunctions within 6 months were excluded from the study

Treatment and study plan

Lumbar puncture

Diagnostic Test

Lumbar puncture to obtain the cerebrospinal fluid and for diagnostic test

Primary outcomes

  1. Length of hospital stay

    Time frame: evaluated 1day after discharge

    Length of hospital stay

  2. modified Rankin Scale

    Time frame: evaluated 1day after discharge

    modified Rankin Scale (mRS) at discharge. mRS ranging from 0-5, higher represents worse

  3. Glasgow Outcome Scale

    Time frame: evaluated 1day after discharge

    Glasgow Outcome Scale (GOS) at discharge, GOS ranging from 0-5, higher represents better

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Official study title

Inhibition of Caspase-1 Reduces Pyroptotic Neuroinflammation and Tissue Factor-Induced Cerebrospinal Fluid Circulation Impairment After Subarachnoid Hemorrhage

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jun 24, 2021
Registry last updated
Jan 6, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.