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OpenTrials
Completed

NCT Number: NCT07052656

Risk Factors and Outcomes in Patients Treated in Neurocritical Care

The overall purpose of this epidemiologic research project is to provide a comprehensive exploration and analysis of critical elements within the neuro-intensive care process in Sweden. All aspects of intensive care management in critically ill patients with acute brain injury will be addressed. The analyses include description of patient characteristics, intensive care data, management and treatments, various aspects of short and long-term follow-up, mortality, regional- and sex-related differences. The long-term goal is to develop neuro-intensive care and management, to minimize in-hospital insults and secondary injuries, to improve diagnostics and follow-up, in order to reduce prolonged neurologic deficits and mortality in these patients.

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Key information

Conditions

Neuro-intensive Care Unit Patients Acute Brain Injuries Acute Neurological Injury Brain Diseases Brain Injuries Brain Injuries, Traumatic Cardiovascular Diseases Central Nervous System Diseases Cerebral Hemorrhage Cerebrovascular Disorders Craniocerebral Trauma Epilepsy Hemorrhage Intracerebral Hemorrhage Intracranial Hemorrhages Ischemic Stroke Meningitis Nervous System Diseases Neuroinflammatory Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Stroke, Acute Subarachnoid Hemorrhage Subarachnoid Hemorrhage, Aneurysmal Trauma, Nervous System Traumatic Brain Injury Vascular Diseases Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Karolinska University Hospital

Stockholm, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ICU admission 2010 to 2024
  • Clinical diagnosis of subarachnoid hemorrhage, intracranial hemorrhage or ischemic brain injury, traumatic brain injury, epilepsy, meningitis, encefalititis or other brain injury diagnosis.

Treatment and study plan

Observational study, participants are not assigned an intervention as part of the study.

Other

Observational study, participants are not assigned an intervention as part of the study.

Transport modality

Other

Transfer modality to tertiary centers

Primary outcomes

  1. Mortality

    Time frame: Up to two years

    Mortality

Secondary outcomes

  1. Morbidity

    Time frame: Up to two years

    Neuropsychiatric diagnoses, depression/anxiety), longterm sick leave, loss of income as a proxy for quality of life

Other outcomes

  1. DAOH90

    Time frame: 90 days

    Days alive and out of hospital

  2. Complications

    Time frame: 90 days

    Rebleeding, secondary insults, cerebral infarctions

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Karolinska University Hospital

Registry information

Acronym: EpiNIC

Important dates

Study start
2010
Primary completion
2024
Study completion
2024
First posted
Jul 4, 2025
Registry last updated
Jul 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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