Skip to main content
OpenTrials
Completed

NCT Number: NCT01489683

Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine

When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Drug Usage

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ajou University School of Medicine

Suwon, 443-721, South Korea

About this study

Anesthesia was induced with propofol-remifentanil TCI with the effect-site concentration of 5μg/ml and 5ng/ml, respectively. After TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, following intubation was performed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture

Exclusion criteria

  • bronchial asthma,
  • COPD,
  • hypertension,
  • anticipated difficult airway

Treatment and study plan

Lidocaine

Drug

3 ml of 4% lidocaine was instilled to larynx and trachea

Other names: 4%lidocaine

normal saline

Drug

3 ml of normal saline was instilled to larynx and trachea before endotracheal intubation

Other names: control

Primary outcomes

  1. Overall acceptable conditions for tracheal intubation

    Time frame: baseline from 5 min of TCI was maintained

    Four minutes after start of propofol-remifentanil TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, and one minute later, intubation was performed in double-blinded fashion.

Sponsors and collaborators

Lead sponsor

Ajou University School of Medicine

Other

Registry information

Official study title

Effect of Tracheal Lidocaine on Intubating Conditions During Propofol-remifentanil TCI Without Neuromuscular Blockade

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Dec 12, 2011
Registry last updated
Jul 16, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.