Skip to main content
OpenTrials
Completed

NCT Number: NCT03965637

Intravenous Ascorbic Acid Administration in Hysterectomy

vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Abdominal Hysterectomy Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 3

Primary location

Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences

Tehran, Iran

About this study

In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To be 18 years and older
  • No smoking
  • No history of bleeding disorder
  • No history of favism
  • No history of uterus, ovary, cervical cancer

Exclusion criteria

  • Need to injection of vasopressor drugs
  • Surgeon disagreement

Treatment and study plan

Vitamin C

Drug

water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection

Other names: ascorbic acid

Primary outcomes

  1. volume of hemorrhage

    Time frame: During surgery

    volume of hemorrhage during surgery

Secondary outcomes

  1. Hemoglobin value

    Time frame: 6 and 24 hours after surgery

    Hemoglobin value after surgery

  2. wound healing

    Time frame: during 2 weeks post surgery

    complications after surgery

  3. duration of stay in hospital

    Time frame: up to 2 weeks post surgery

    Length of stay in hospital

  4. Infection

    Time frame: up to 2 weeks post surgery

    Developing infection up to 2 weeks

Sponsors and collaborators

Lead sponsor

Shahid Beheshti University

Other

Registry information

Official study title

Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
May 29, 2019
Registry last updated
May 4, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.