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OpenTrials
Completed

NCT Number: NCT05988671

Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

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Key information

Conditions

Laparoscopic Cholecystectomy Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Haney Baumey, Banhā, Egypt

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged from 20 - 50 years
  • ASA I OR II
  • undergo laparoscopic cholecystectomy

Exclusion criteria

  • Patients with history of psychotic illnesses,
  • Parkinson's disease
  • motion disorder
  • Smoker
  • or history of chemotherapy

Treatment and study plan

normal saline

Drug

Intraperitoneal route

Dexamethasone

Drug

Intraperitoneal route

Dexmedetomidine

Drug

Intraperitoneal route

Combination of dexamethasone + dexmedetomidine

Drug

Intraperitoneal route

Primary outcomes

  1. The number of patients suffered from postoperative nausea and vomiting will be recorded in each group.

    Time frame: 24 hours postoperative

Secondary outcomes

  1. antiemetic consumption

    Time frame: 24 hours postoperatively

    frequency of antiemetic consumption will be determined

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Collaborators

  • Benha University

Registry information

Official study title

Comparison of Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Clinical Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Aug 14, 2023
Registry last updated
Jun 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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