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NCT Number: NCT07190495

Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy

This study aims to evaluate whether preoperative oral administration of ginger (800 mg, given 2 hours before surgery) reduces the incidence and severity of postoperative nausea and vomiting (PONV) within the first 24 hours after laparoscopic cholecystectomy.

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Key information

Conditions

Postoperative Nausea and Vomiting Laparoscopic Cholecystectomy Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years.
  • Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
  • American Society of Anesthesiologists (ASA) physical status I-III.
  • Able to understand the study procedures and provide written informed consent.

Exclusion criteria

  • Known allergy or hypersensitivity to ginger
  • Documented history of bleeding disorders or current treatment with anticoagulant agents
  • History of severe postoperative nausea and vomiting or an Apfel score of 4
  • Administration of antiemetic drugs or corticosteroids during the preoperative period
  • Pregnancy or breastfeeding
  • Active gastrointestinal or liver disease

Treatment and study plan

Ginger

Drug

Patients will receive 800 mg of oral ginger 2 hours before laparoscopic cholecystectomy

Placebo

Drug

Patients will receive an oral placebo capsule identical in appearance to ginger, administered 2 hours before laparoscopic cholecystectomy

Primary outcomes

  1. Incidence of postoperative nausea and vomiting (PONV) within 2 hours post-surgery

    Time frame: 2 hours after surgery.

    Occurrence of at least one episode of nausea or vomiting within the first 2 hours after surgery.

Secondary outcomes

  1. Recurrence of PONV beyond 2 hours postoperatively

    Time frame: From 2 hours to 24 hours after surgery.

    Proportion of participants who experienced at least one additional episode of nausea or vomiting occurring after the 2-hour postoperative time point.

  2. Incidence of postoperative nausea and vomiting (PONV) within 24 hours post-surgery

    Time frame: 24 hours after surgery.

    Occurrence of at least one episode of nausea or vomiting within the first 24 hours after surgery.

  3. Total number of vomiting episodes

    Time frame: Within 24 hours post-surgery.

    Cumulative number of vomiting episodes recorded per participant during the first 24 hours after surgery.

  4. Use of rescue antiemetics

    Time frame: 24 hours postoperatively

    The need for rescue antiemetics within 24 hours postoperatively.

  5. Incidence of ginger-related adverse events

    Time frame: Within 24 hours after surgery

    Number of participants experiencing adverse events known to be associated with ginger, including gastrointestinal discomfort (heartburn, abdominal pain, bloating, diarrhea), bleeding, or allergic reactions in the 24 hours after surgery.

Study contacts

Contact information is provided by the study sponsor or research team.

Ibtissem BEN TALEB, M.D.

CONTACT

[email protected]

+216 23 133 748

Sponsors and collaborators

Lead sponsor

University Tunis El Manar

Other

Registry information

Official study title

Preoperative Ginger for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Double-Blind Randomized Controlled Trial

Acronym: GINGER-PONV

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 24, 2025
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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