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NCT Number: NCT02179437

Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery

Postoperative pain can be severe after liver resection surgery. However, postoperative pain management may be difficult for this group of patients. Opioidergic neurotransmission may be altered in cirrhotic patients and selectively increasing receptor affinity for opioids. Large dose of strong opioid may be required to achieve adequate pain control. However, this may not be possible due to the side effect of opioid and liver dysfunction after liver resection.

Propofol is a commonly used anaesthetic with rapid recovery and less side effects and TIVA (total intravenous analgesia) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery.

Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result.

The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing liver resection surgery at Queen Mary Hospital, Hong Kong between 2010 to 2012.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anaesthesiology, The University of Hong Kong

Hong Kong, China

About this study

Retrospective audit.

Anaesthetic records and acute pain service records of patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital would be retrieved from the computer.

Data Collection

  • Demographic data;
  • Types of analgesic techniques;
  • Type of pain relief modalities;
  • Pain score up to 72 hours postoperatively;
  • Postoperative opioid consumption;
  • Incidence of adverse events during APS care;
  • Patients' satisfaction on pain relief.

Data Analysis For summarising analysis, mean or median with standard deviation or interquartile range will be reported. Parametric and non-parametric comparative tests will be used for analysis between/among patients with various characteristics. Kaplan Meier survival analysis and log-rank test will be used for duration of APS use.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital

Exclusion criteria

  • Essential data were missing.
  • Patient participating in other research projects.
  • Changes in postoperative pain management technique.
  • Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Treatment and study plan

Primary outcomes

  1. Postoperative pain score

    Time frame: From postoperative 1 hour to postoperative 72 hour

Secondary outcomes

  1. Adverse event

    Time frame: From postoperative 1 hour to postoperative 72 hour

Other outcomes

  1. Analgesic consumption

    Time frame: From postoperative 1 hour to postoperative 72 hour

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Official study title

Retrospective Study to Investigate Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jul 1, 2014
Registry last updated
May 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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