Intraoperative "p50" Measurement in Liver Transplant Surgeries

The aim of this study is to compare the p50 value in routine blood gas measurements taken during liver transplant surgery follow-up with other follow-up parameters and clinical findings on the monitors, and to investigate whether there is a predictive parameter that can predict the rapidly changing clinical findings of the patients.

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Key information

Conditions

Liver Transplant; Complications

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

İnönü Üniversitesi Merkez Kampüsü (Elazığ Yolu 15.km) Battalgazi

Malatya, 44280, Turkey (Türkiye)

About this study

Blood gas monitoring is the most commonly method used by anesthetists during liver transplant surgeries. We evaluated the blood gas p50 value according to the stages in these heart transplant operations. We tried to find out how the blood gas p50 value would guide the patient's clinical findings in the dissection phase, anhepatic phase and neohepatic phase. For this purpose, we compared arterial and venous blood gas p50 values with the patient's vital signs at certain stages in liver transplant surgeries.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Liver transplant recipients who will undergo Elective Liver Transplant surgery at İnönü University Faculty of Medicine Liver Transplant Institute, ASA (American Society of Anesthesiology) score III-IV, patients between the ages of 18-65

Exclusion criteria

Patients with fulminant liver failure,
hepatic encephalopathy,
hepatorenal,
hepatopulmonary syndrome,
uncontrolled diabetes mellitus,
cardiovascular, pulmonary disease,
sepsis
and patients who refuse consent in the informed consent form will be excluded from the study.

Treatment and study plan

Primary outcomes

p50 changes during liver transplant surgery

Time frame: T0: at the end of the dissection before clamps T1: 5 min. before reperfusion (anhepatic) T2: 30 min. after reperfusion of the liver graft (neohepatic) T3: after hepatic artery reperfusion T4: End of the operation

P50 is the partial pressure of oxygen required to achieve 50% haemoglobin saturation. The normal p50 value is 24-28 mmHg. The oxygen-hemoglobin dissociation curve represents the affinity of hemoglobin for oxygen. The p50 value represents a mid-point in this curve, and gives us information regarding that affinity. Determining the clinical value, if any, of the changes in p50 values taken at different stages of liver transplantation surgery may be useful in the follow-up of these patients in the future and may help in making intraoperative decisions.

Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Official study title

"Investigation of the Clinical Predictive Value of p50 Value in Liver Transplant Surgeries"

Acronym: p50

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Oct 26, 2024
Registry last updated: Oct 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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