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Completed

NCT Number: NCT03733509

Intraoperative Direct vs Postoperative Ultrasound Guided Adductor Canal Nerve Block After Total Knee Arthroplasty

This study compares analgesic effect between two techniques of adductor canal nerve block after total knee arthroplasty. The first group of the patients will receive intraoperative adductor canal nerve block; and the other group post operative ultrasound guided adductor canal nerve block. Investigators will measure postoperative opioid consumption, pain management and rehabilitation goals.

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Key information

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pontificia Universidad Católica de Chile

Santiago, Santiago Metropolitan, 8330024, Chile

About this study

Total knee arthroplasty (TKA) is a successful alternative to treat late stage knee osteoarthritis (OA). Pain management has been one of the main focuses of postoperative care. Most surgeons prefer a comprehensive multimodal approach including preoperative pharmacological treatment, intraoperative infiltration with complex drug mixes and postoperative peripheral nerve block.

The most common postoperative nerve block alternative is the proximal femoral nerve block (FNB) which has shown improvements on postoperative pain measured by reduced opioid consumption and decreased pain at rest. Its main detractors argue that the motor nerve block effect is deleterious to early ambulation and have promoted adductor canal nerve blocks (ACB). Described by Lund et al in 2011, ACB block main femoral pain sensory contributors to the knee (articular branches of obturator nerve, vastus medialis branch and saphenous nerve) but is more distal to most motor branches to the quadriceps allowing near to normal quadriceps strength.

Standard ACB block is performed under ultrasound guidance after surgery completion, still in the operating room (OR). Recent literature has shown the anatomic feasibility of intraoperative ACB via blunt suprapatellar dissection in standard medial parapatellar TKA approaches. The study seeks to determine the effectiveness of standard ultrasound guidance ACB compared with intraoperative ACB.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Primary total knee arthroplasty
  • Unilateral
  • American Society of Anesthesiologists (ASA) score I, II or III
  • Accepts spinal anesthesia

Exclusion criteria

  • General anesthesia
  • Chronic kidney disease
  • Drug or alcohol abuse
  • Chronic opioid use
  • Allergic to bupivacaine or similar

Treatment and study plan

Intraoperative Block

Procedure

One shot adductor canal nerve block with 20ml of bupivacaine 0.25% through surgical incision

Ultrasound Block

Procedure

One shot adductor canal nerve block with 20ml of bupivacaine 0.25% mid-thigh

Intraoperative Placebo

Procedure

One shot adductor canal nerve infusion with 20ml of saline solution through surgical incision

Ultrasound Placebo

Procedure

One shot adductor canal nerve infusion with 20ml of saline solution mid-thigh

Primary outcomes

  1. 24 hour opioid consumption

    Time frame: First 24 hours after surgery

    Opioid consumption by patient controlled analgesia (PCA) and any other oral or IV analgesics

Secondary outcomes

  1. 24 patient reported pain

    Time frame: First 24 hours after surgery

    Patient reported pain scale using visual analog scale (VAS) every 6 hours after surgery (0 hours, 6 hours, 12 hours, 18 hours and 24 hours)

  2. Time up and go Test

    Time frame: 24 hours after surgery

    Standardised test to determine patients ability to walk 24 hours after surgery

  3. Time to Discharge

    Time frame: 7 days

    Time between surgery and patient in conditions for discharge: no IV requirements, basic walking capability and VAS pain score equal or below 3

  4. Range of motion

    Time frame: 24 hours after surgery

    Active and passive knee range of motion

Sponsors and collaborators

Lead sponsor

Pontificia Universidad Catolica de Chile

Other

Registry information

Official study title

Intraoperative Direct Adductor Canal Nerve Block Versus Post Operative Ultrasound Guided Adductor Canal Nerve Block in Total Knee Arthroplasty: a Double-blind Randomized Trial

Important dates

Study start
2018
Primary completion
2022
Study completion
2022
First posted
Nov 7, 2018
Registry last updated
Oct 26, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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