Skip to main content
OpenTrials
Completed

NCT Number: NCT07442240

Intradialytic Rehabilitation and Functional Independence in Hemodialysis Patients

This study evaluated whether a rehabilitation program performed during hemodialysis sessions could improve daily functioning and mobility in adults receiving maintenance hemodialysis. Participants took part in either exercise-based rehabilitation, breathing muscle training, or usual care. The study compared changes in functional independence and mobility before and after the rehabilitation period.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chronic Kidney Disease (stages 4 and 5) Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hemodialysis Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

25 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

This academic clinical study was conducted in two dialysis centers in Istanbul between June 2016 and March 2017. Adults undergoing maintenance hemodialysis were allocated to one of three groups: dynamic lumbar stabilization exercises, inspiratory muscle training, or a control group receiving routine nephrological care.

Participants in the intervention groups completed a supervised intradialytic rehabilitation program three times per week for 10 weeks. Functional independence and mobility-related performance were assessed at baseline and after completion of the intervention using validated functional assessment measures. The study was conducted as part of a doctoral thesis and is being retrospectively registered for transparency.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 25 to 45 years.
  • Diagnosis of chronic kidney disease undergoing maintenance hemodialysis.
  • Receiving hemodialysis for at least 6 months.
  • Hemodialysis schedule of three sessions per week, four hours per session.
  • Clinically stable at the time of enrollment.
  • Ability to participate in exercise and functional assessments.
  • Provided written informed consent.

Exclusion criteria

  • Acute medical conditions or unstable cardiovascular disease.
  • Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise participation.
  • Severe cognitive impairment or inability to follow instructions.
  • Uncontrolled hypertension or other conditions contraindicating exercise.
  • Participation in another structured exercise or rehabilitation program during the study period.

Treatment and study plan

Dynamic Lumbar Stabilization Exercises

Behavioral

A structured intradialytic exercise program focusing on trunk stabilization and neuromuscular control, performed under supervision during hemodialysis sessions.

Respiratory muscle training

Behavioral

Respiratory muscle training performed during hemodialysis using threshold-based breathing exercises under supervision.

Primary outcomes

  1. Six-Minute Walk Test

    Time frame: Baseline and after 10 weeks

    Functional exercise capacity assessed as the distance walked in six minutes, measured according to standardized procedures.

Secondary outcomes

  1. Timed Up and Go Test (TUG)

    Time frame: Baseline and after 10 weeks

    Functional mobility assessed by the time required to stand up from a chair, walk three meters, turn, walk back, and sit down.

  2. Five Times Sit-to-Stand Test (5STS)

    Time frame: Baseline and after 10 weeks

    Lower extremity functional performance assessed as the time required to complete five consecutive sit-to-stand movements.

  3. Maximal Inspiratory Pressure (MIP)

    Time frame: Baseline and after 10 weeks

    Inspiratory muscle strength measured as maximal inspiratory pressure using standardized respiratory pressure measurement techniques.

  4. Maximal Expiratory Pressure (MEP)

    Time frame: Baseline and after 10 weeks

    Expiratory muscle strength measured as maximal expiratory pressure using standardized respiratory pressure measurement techniques.

  5. Forced Vital Capacity (FVC)

    Time frame: Baseline and after 10 weeks

    Pulmonary function assessed as forced vital capacity measured by spirometry according to standard guidelines.

  6. Forced Expiratory Volume in 1 Second (FEV1)

    Time frame: Baseline and after 10 weeks

    Pulmonary function assessed as forced expiratory volume in one second measured by spirometry according to standard guidelines.

Sponsors and collaborators

Lead sponsor

Bandırma Onyedi Eylül University

Other

Registry information

Official study title

Effects of Intradialytic Dynamic Lumbar Stabilization Exercises and Inspiratory Muscle Training on Functional Independence in Patients Undergoing Maintenance Hemodialysis

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Mar 2, 2026
Registry last updated
Mar 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.