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Completed

NCT Number: NCT05357521

Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder

This study aims to determine the feasibility and preliminary data on the interaction between oxytocin and cortisol during stress in borderline personnality disorder.

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Key information

Conditions

Borderline Personality Disorder Mental Disorders Oxytocin Personality Disorders

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

Young Adult Psychiatric Unit

Geneva, Canton of Geneva, 1202, Switzerland

About this study

The investigators will recruit 50 female patients with borderline personnality disorder and 50 controls with no psychiatric diagnosis, aged between 18 and 25 years old.

salivary cortisol daily curve ( 6 measures during the day) will be measured in participant's naturalistic environnement, together with salivary oxytocin. In addition, salivary oxytocin and cortisol will be measured during a psychosocial stress task and recovery.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Borderline personality disorder-DSM V

Exclusion criteria

  • Schizophrenia

Treatment and study plan

stress test

Other

TSST- psychosocial stress test

Primary outcomes

  1. Salivary cortisol

    Time frame: Baseline

    salivary cortisol measured with salivettes (swabs)

  2. Salivary cortisol

    Time frame: Change in one day (circadian cortisol with 6 measures within one day

    salivary cortisol measured with salivettes (swabs)

  3. Salivary cortisol

    Time frame: Change during experimental task (up to 2 hours)

    salivary cortisol measured with salivettes (swabs)

  4. Salivary oxytocin

    Time frame: Baseline

    salivary oxytocin measured with salivettes (swabs)

  5. Salivary oxytocin

    Time frame: Two measures within one day

    salivary oxytocin measured with salivettes (swabs)

  6. Salivary oxytocin

    Time frame: Change during experimental task (up to 2 hours)

    salivary oxytocin measured with salivettes (swabs)

Sponsors and collaborators

Lead sponsor

University of Geneva, Switzerland

Other

Registry information

Official study title

Feasibility and Preliminary Data on the Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder

Acronym: OXT-CORT-BPD

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
May 3, 2022
Registry last updated
May 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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