Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
GROUP A: Germline and Somatic Testing
- Has Mayo Clinic medical record number
- Confirmed cancer diagnosis
- Germline and/or somatic tumor/blood testing has been ordered by the clinical provider (or clinical delegate)
- Participant aware of cancer diagnosis
- Able to provide informed consent
- ≥ 18 years old
- Ability to provide blood, saliva, bone marrow aspirate or hair follicle sample
- Ability to provide archived tissue, if somatic testing has not already been completed
- Note: if tissue unavailable participant may still enroll onto the study for the germline collection, or vice versa, if germline has already been completed may still enroll for somatic tissue/blood testing.
GROUP B: Germline testing only:
- Has Mayo Clinic medical record number
- Confirmed cancer diagnosis
- Germline testing has been ordered by the clinical provider (or clinical delegate)
- Participant aware of cancer diagnosis
- Able to provide informed consent
- ≥ 18 years old
- Ability to provide blood, saliva, or hair follicle sample
GROUP C: Somatic tumor testing only:
- Has Mayo Clinic medical record number,
- Confirmed cancer diagnosis,
- Somatic tumor/blood testing has been ordered by the clinical provider (or clinical delegate)
- Participant aware of cancer diagnosis,
- Able to provide informed consent,
- ≥ 18 years old
- Ability to provide archived tissue or blood for somatic tumor genomic profiling, if not already completed.
Group D: Clinical standard of care germline testing via genetic counselor:
- Has Mayo Clinic medical record number,
- Standard of care clinical visit with genetic counselor
- Confirmed cancer diagnosis,
- Germline testing has been ordered by the clinical provider (or clinical delegate)
- Participant aware of cancer diagnosis,
- Able to provide informed consent,
- ≥ 18 years old
- Ability to provide blood, saliva, or hair follicle sample
Group E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810:
- Enrolled in any of the following studies: IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810
- Completed Riskguard, OncoExtra, Caris Assure, or Caris MI Profile or any combination of these tests.
- Has Mayo Clinic medical record number,
- Confirmed cancer diagnosis,
- Participant aware of cancer diagnosis
- Able to provide informed consent,
- ≥ 18 years old
Exclusion criteria
Note: Women who are pregnant or planning to become pregnant can take part in this study.
GROUP A: Germline and Somatic testing
- Individuals who have situations that would limit compliance with the study requirements
- Institutionalized (i.e. Federal Medical Prison)
GROUP B: Germline testing only
- Individuals who have situations that would limit compliance with the study requirements
- Institutionalized (i.e. Federal Medical Prison)
- Prior germline genetic testing with a 100+ multi-gene panel within the last 1 year of enrollment
Group C: Somatic tumor testing only:
- Individuals who have situations that would limit compliance with the study requirements,
- Institutionalized (i.e. Federal Medical Prison),
Group D: Clinical standard of care germline testing via genetic counselor:
- Individuals who have situations that would limit compliance with the study requirements,
- Institutionalized (i.e. Federal Medical Prison)
Group E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810:
- Individuals who have situations that would limit compliance with the study requirements,
- Institutionalized (i.e. Federal Medical Prison)
