Interest of MRI in Preoperative Staging for the Laryngeal and Hypopharyngeal Cancer

To determine if MRI can detect preoperative invasion of cartilage by laryngeal and hypopharyngeal carcinoma, and to compare it to CT imaging and histopathology in excised larynges and/or hypopharynges.

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Key information

Conditions

Hypopharyngeal Carcinoma Head and Neck Neoplasms Hypopharyngeal Neoplasms Laryngeal Carcinoma Laryngeal Diseases Laryngeal Neoplasms Neoplasms Neoplasms by Site Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Pharyngeal Diseases Pharyngeal Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Service ORL et chirurgie cervico-faciale, Hôpital de la Croix rousse

Lyon, 69004, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient ≥18 years old
Patient with a laryngeal or hypopharyngeal cancer at any stage
Patient eligible for a surgical treatment in multidisciplinary consultation
Patient who did not oppose its participation to the study
Indication for performing an MRI in addition to CT at the discretion of the investigator

Exclusion criteria

Patient with an ASA ("American Society of Anesthesiologists", international anesthesia classification) score ≥ 3,
Patient with a chirurgical contraindication
Patient with a MRI contraindication
Pregnant or nursing woman
Adult requiring protection (guardianship, supervision)
Patient participating in interventional research (Excluding physiological studies and interventional research involving only minimal risks and constraints that do not interfere with the analysis of the primary outcome).

Treatment and study plan

Pharyngo laryngeal MRI

Other

Patients will be outgoing a pharyngolaryngeal MRI, with injection of gadolinium, in addition to the CT imaging. They will have this MRI in case of doubt about cartilage invasion. It will be realised during the time between the CT imaging and the day of surgery.

Device : gadolinium-based MRI contrast agent This will be realized according to the standard procedure.

Primary outcomes

Endoscopy

Time frame: 1-4 weeks

Tumor stage and cartilage invasion as determined by endoscopy : invaded/non invaded/undetermined
CT scan

Time frame: 1-4 weeks

Tumor stage and cartilage invasion as determined by CT scan : invaded/non invaded/undetermined
MRI

Time frame: 1-4 weeks

Tumor stage and cartilage invasion as determined by MRI : invaded/non invaded/undetermined
Anatomopathological analysis

Time frame: 2-4 weeks

Tumor stage and cartilage invasion as determined by histopathology in excised pieces : invaded/non invaded/undetermined

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: Larynx MRI

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Apr 28, 2017
Registry last updated: Apr 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed