Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07484594

Integrated Trunk Stabilization With Osteoarthritis Rehabilitation in Knee-Spine Syndrome

This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome. It further examines whether improving trunk stability can reduce knee pain and enhance functional outcomes in knee osteoarthritis

Recruiting

Interested in participating?

Request Info

Key information

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bahria Active Hospital, Islamabad, AL, Pakistan

Loading trial locations.

About this study

This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation protocols for patients with knee-spine syndrome. It seeks to determine whether improving trunk stability can positively influence knee joint mechanics, leading to a reduction in knee pain and improvements in physical function, mobility, and overall functional performance in individuals with knee osteoarthritis. The findings may support a more comprehensive rehabilitation approach addressing both spinal and knee involvement in osteoarthritis management.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 40-60 years
  • Both Genders
  • Bilateral Knee osteoarthritis diagnosed according to the American College of Rheumatology Clinical Classification system
  • Kellgren & Lawrence grade 2 and 3 with complaint of pain, crepitations, stiffness and bony enlargement
  • History of backpain for the past 3 months with no complaint of radiating pain
  • Able to walk independently/unaided

Exclusion criteria

  • Kellgren & Lawrence grade 4
  • Intra-articular corticosteroid injections in the last 3 months or hyaluronic knee injection in the previous 6 months.
  • History of lower limb or lumbar trauma/surgery, presence of fracture or deformity, or planned surgery within the study period
  • Lumbar pathologies, for example, spondylolisthesis, ankylosing spondylitis, or any diagnosed severe cardiovascular, pulmonary, neurological, or psychological disease or impairment except lumbar spondylosis
  • BMI>30
  • Presence of infection, cauda equina syndrome, or meningitis

Treatment and study plan

Trunk Stabilization exercises with conventional Rehab

Other

The protocol for will be followed for 6 weeks, where individuals will perform trunk stabilization exercises with conventional rehabilitation for knee osteoarthritis.

conventional rehabilitation

Other

The protocol for will be followed for 6 weeks, where conventional rehabilitation for knee osteoarthritis will be implemented.

Primary outcomes

  1. Visual Analogue Scale

    Time frame: 6 weeks

    The Visual Analog Scale (VAS) is a simple and reliable tool for assessing pain intensity on a continuous visual scale. The extreme limits of pain are represented by the straight line's ends, where 0 indicates no pain, and 10 indicates the worst pain a person has ever felt.

  2. Western Ontario and McMaster Universities Arthritis Index (WOMAC)

    Time frame: 6 weeks

    It is widely used in the evaluation of knee osteoarthritis to assess activities of daily living, functional mobility, gait, general health, and quality of life. It has 24 items divided into 3 subscales: pain (5 items), stiffness (2 items), and physical function (17 items). The scores range from 0 to 4 for each subscale. The score ranges from 0 to 96, where zero indicates no pain, stiffness, and functional limitation. Higher scores indicate worse pain, stiffness, and functional limitation.

Secondary outcomes

  1. Range Of motion (ROM)

    Time frame: 6 weeks

    A Goniometer is used to measure active and passive ROM for knee flexion and extension while the patient lies supine

  2. Time-Up-and-Go (TUG)

    Time frame: 6 weeks

    This test is a widely used assessment of functional mobility, particularly in patients with knee osteoarthritis. The test measures the total time it takes for a patient to stand up from a chair, walk 3 meters at a comfortable pace, turn around, walk back to the chair, and sit down. A shorter time indicates better functional performance

  3. Oswestry Disability Index (ODI)

    Time frame: 6 weeks

    It is a questionnaire that gives a subjective percentage score of level of function/disability in activities of daily living of patients with low back pain. It contains 10 items, each scored from 0 to 5, with the total score converted to a percentage ranging from 0% to 100%. Higher percentages indicate greater disability, i.e., worse outcomes, while lower percentages indicate less disability/better outcomes.

  4. Flexicurve (Lumbar Range of motion)

    Time frame: 6 weeks

    Flexicurve is a flexible plastic-coated metal ruler molded to the lumbar spine's sagittal contour (typically T12 to S1) to non-invasively measure lordosis angle via traced perpendicular heights, serving as a radiation-free alternative to X-rays

Study contacts

Contact information is provided by the study sponsor or research team.

Imran Amjad, PhD

CONTACT

[email protected]

03324390125 ext. 03324390125

Suman Sheraz, PhD

CONTACT

[email protected]

03335646361 ext. 03335646361

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Integrating Trunk Stabilization Exercises With Conventional Rehabilitation Protocol for Osteoarthritis in Patients With Knee-Spine Syndrome

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 20, 2026
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.