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NCT Number: NCT07220681

Integrated Health Care for PTSD

The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with posttraumatic stress disorder (PTSD). The main aims are:

1. To evaluate the impact of integrative care approaches on functional outcomes among Veterans with PTSD. 2. To examine factors relevant to the implementation of integrated treatments for PTSD from the perspective of patients, providers and administrators in the VA Healthcare System.

Participants will:

1. Complete assessments at the beginning of the study and 12- and 24-weeks later. 2. Engage in 12 weeks of integrated care, with the type being randomly assigned.

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Key information

Conditions

Posttraumatic Stress Disorder (PTSD) Mental Disorders Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Trauma and Stressor Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Central Arkansas Healthcare System, Little Rock, Arkansas, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical diagnosis
  • eligibility for Cognitive Processing Therapy (CPT) at a participating VA site
  • able to consent to study activities

Exclusion criteria

  • current, active engagement in one of the included approaches (per clinician judgment)
  • medical conditions that contraindicate engaging in the experimental interventions

Treatment and study plan

Yoga and meditation

Behavioral

12 weekly 60-minute hatha yoga classes and access to video-based training in a portable mantra-based meditation practice

Wellness

Behavioral

12 weekly 60-minute classes to provide education about exercise and nutrition and facilitate lifestyle changes

Positive affect

Behavioral

12 weekly 60-minute classes to teach strategies for increasing positive affect and to provide social connection

Information

Other

Provision of written information about local and national complementary and integrative care resources

Primary outcomes

  1. Inventory of Psychosocial Functioning (IPF)

    Time frame: weeks 0, 12 and 24

    The IPF is a self-report measure of functioning across several domains. It is summarized in a mean score with higher scores indicating greater functional impairment.

Secondary outcomes

  1. Clinician Administered PTSD Scale for DSM-5 Revised (CAPS-5R)

    Time frame: weeks 0, 12 and 24

    The CAPS-5R is a clinician-administered measure of PTSD symptom severity summarized in a total score with higher scores indicating greater symptom severity.

  2. Quick Inventory of Depressive Symptomatology (QIDS)

    Time frame: weeks 0, 12 and 24

    The QIDS is a self-report measure of depression severity summarized by a total score for which higher scores reflect greater symptom severity.

  3. Insomnia Severity Index (ISI)

    Time frame: weeks 0, 12 and 24

    The ISI is a self-report measure that assesses the consequences of and distress related to insomnia summarized by a total score in which higher scores indicate greater sleep disruption.

Study contacts

Contact information is provided by the study sponsor or research team.

Ariel J Lang, PhD, MPH

CONTACT

[email protected]

858-552-8585 ext. x5359

Haley Suit, MA

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Veterans Medical Research Foundation

Other

Collaborators

  • United States Department of Defense

Registry information

Official study title

A Hybrid I Evaluation of Integrative Health Care for PTSD

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Oct 24, 2025
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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