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Completed

NCT Number: NCT05067062

Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses

Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.

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Key information

Conditions

no Conditions

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Mark Willems

Chichester, West Sussex, PO19 6PE, United Kingdom

About this study

The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Non-smokers
  • Not taking any supplements
  • No known allergy to berries or berry products

Exclusion criteria

  • Sedentary
  • Known high blood pressure
  • Smoking
  • On medication

Treatment and study plan

New Zealand blackcurrant extract

Dietary Supplement

Capsules taken daily or intermittent

Primary outcomes

  1. Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

    Time frame: baseline, acute, one week and two weeks

    The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.

    Heart rate will be measured in beats/min.

  2. Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

    Time frame: baseline, acute, one week and two weeks

    The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.

    Stroke volume will be measured in mL.

  3. Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

    Time frame: baseline, acute, one week and two weeks

    The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.

    Cardiac output will be measured in L/min.

  4. Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

    Time frame: baseline, acute, one week and two weeks

    The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.

    Systolic, diastolic and mean arterial blood pressure will be measured in mmHg.

  5. Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

    Time frame: baseline, acute, one week and two weeks

    The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.

    Total peripheral resistance will be measured in (mmHg·min)/L

Secondary outcomes

  1. Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.

    Time frame: baseline, acute, one week and two weeks

    The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.

    Oxygen consumption will be measured in L/min

  2. Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.

    Time frame: baseline, acute, one week and two weeks

    The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.

    Carbon dioxide production will be measured in L/min.

  3. Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.

    Time frame: baseline, acute, one week and two weeks

    The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.

    Respiratory exchange ratio is unitless and calculated from the ratio of carbon dioxide production and oxygen consumption.

  4. Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.

    Time frame: baseline, acute, one week and two weeks

    The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.

    Carbohydrate oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.

  5. Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.

    Time frame: baseline, acute, one week and two weeks

    The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.

    Fat oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.

Sponsors and collaborators

Lead sponsor

University of Chichester

Other

Registry information

Official study title

Effects of Intake Duration of New Zealand Blackcurrant Extract on Physiological, Cardiovascular and Metabolic Responses at Rest and During Moderate-intensity Exercise in Healthy Males

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Oct 4, 2021
Registry last updated
Oct 4, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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