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Recruiting

NCT Number: NCT04666246

Inspiratory Effort in COVID-19

This study aims at assessing esophageal pressure in patients with acute respiratory failure due to COVID-19 undergoing non invasive respiratory support.

Recruiting

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Key information

Conditions

Acute Respiratory Failure COVID-19 Coronaviridae Infections Coronavirus Infections Covid19 Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital of Modena

Modena, 41124, Italy

Location status: Recruiting

Location contact

Alessandro Marchioni, MD

CONTACT

[email protected]

0039 0594225859

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COVID-19
  • Acute respiratory failure undergoing non-invasive respiratory support

Exclusion criteria

  • Need for immediate endotracheal intubation
  • Chronic respiratory diseases

Treatment and study plan

Primary outcomes

  1. Inspiratory effort quantification

    Time frame: 24 hours from admission

    Esophageal pressure assessment through dedicated esophageal pressure transducer

Secondary outcomes

  1. Non invasive respiratory support failure

    Time frame: 24 hours

    Reaching of the criteria for endotracheal intubation

Study contacts

Contact information is provided by the study sponsor or research team.

Alessandro Marchioni, MD

CONTACT

[email protected]

0039 0594225859

Roberto Tonelli, MD

CONTACT

[email protected]

0039 0594225934

Sponsors and collaborators

Lead sponsor

University of Modena and Reggio Emilia

Other

Registry information

Official study title

Inspiratory Effort Assessment in Patients With COVID-19 Pneumonia Undergoing Non Invasive Respiratory Support

Acronym: PERSIA

Important dates

Study start
2020
Primary completion
2024
Study completion
2030
First posted
Dec 14, 2020
Registry last updated
Apr 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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