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Completed

NCT Number: NCT01957293

Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects

Aim is to investigate the effect of beta2 adrenergic stimulant salbutamol on emotional and cognitive functions in healthy humans.

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Key information

Conditions

Memory Functions

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Basel, Division of Cognitive neuroscience

Basel, 4055, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy, male and female, aged between 18 and 40, BMI be-tween 19 and 27 kg/m2, normotensive (BP between 90/60 mmHg and 140/90 mmHg), native or fluent German-speaking, caucasian (European ancestry), able and willing to give written informed consent and comply with the requirements of the study protocol, willing to donate saliva sample for DNA-analysis -

Exclusion criteria

Acute or chronic psychiatric or somatic disorder, tachycardia at rest (> 100 bpm), known hypersensitivity to salbutamol, pathological ECG, pregnancy, breast-feeding, long-term medication within last 3 months (oral contraceptives are disregarded) smoking (>3 cigarettes per day), concurrent participation in another study, participation in one of our previous studies using the same memory tests, inability to read and understand the participant's information. -

Treatment and study plan

Salbutamol

Drug

single oral administration, 4 mg

Placebo

Drug

single oral administration

Primary outcomes

  1. Change of emotional memory functions under Salbutamol

    Time frame: two testing days within 10 days

    memory tests

  2. Change of episodic memory functions under Salbutamol

    Time frame: two testing days within10 days

    memory tests

Secondary outcomes

  1. Change of emotional state under salbutamol

    Time frame: Two testing days within 10 days

    questionnaires

  2. change of attention functions under salbutamol

    Time frame: two testing days within 10 days

    attention tests

Sponsors and collaborators

Lead sponsor

Prof. Dominique de Quervain, MD

Other

Collaborators

  • Clinical Trial Unit, University Hospital Basel, Switzerland

Registry information

Acronym: Salmon-Basel

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Oct 8, 2013
Registry last updated
Dec 16, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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