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OpenTrials
Completed

NCT Number: NCT01599962

Influence of Cincalcet on Cognitive Functions in Healthy Human Subjects

To investigate the effects of the calcimimetic agent cinacalcet on cognitive functions in healthy humans.

Completed

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Key information

Conditions

Memory Functions

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Basel, Division of Cognitive Neuroscience

Basel, 4055, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy
  • normotensive
  • native or fluent German-speaking
  • caucasian (European ancestry)
  • BMI between 19 and 27 kg/m2

Exclusion criteria

  • acute or chronic psychiatric or somatic disorder
  • pathological ECG
  • Low serum calcium
  • known hypersensitivity to the IMP
  • pregnancy
  • breast-feading
  • long-term medication within last 3 months
  • smoking more than 3 cigarettes per day
  • seizures in participants and first degree relatives
  • concurrent participation in another study

Treatment and study plan

Cinacalcet

Drug

single administration, 90mg

Placebo

Drug

single administration

Primary outcomes

  1. Change of attention functions under cinacalcet

    Time frame: two study days within 10 days

  2. Change of memory functions under cinacalcet

    Time frame: two testing days within 10 days

Secondary outcomes

  1. Change of emotional state under cinacalcet

    Time frame: two study days within 10 days

Sponsors and collaborators

Lead sponsor

Prof. Dominique de Quervain, MD

Other

Collaborators

  • Clinical Trial Unit, University Hospital Basel, Switzerland

Registry information

Acronym: Mira-Basel

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
May 16, 2012
Registry last updated
Oct 3, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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