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Completed

NCT Number: NCT04712578

Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance

This study is a randomized, double-blind, placebo-controlled crossover trial examining the effects of caffeinated and non-caffeinated pre-workout supplements on resistance exercise performance. Resistance-trained adults will be randomly assigned to complete three study conditions (caffeinated pre-workout, non-caffeinated pre-workout, and placebo) in one of the six possible condition orders. During each condition, participants will report to the laboratory for ingestion of the assigned beverage and subsequent muscular performance testing. Major performance outcomes will be force production variables from a mechanized squat device and maximal strength and muscular endurance on the bench press and leg press exercises.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Kinesiology & Sport Management

Lubbock, Texas, 79409, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18 and 40;
  • Body mass between 50 - 100 kg (110-220 lb)
  • Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplements or performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).
  • Resistance-trained, defined as completing 2+ resistance training sessions per week for at least three months prior to screening.
  • Participants must have reported regular training of the lower body through a multi-joint exercise such as the squat or leg press at least once weekly during the three-month period prior to screening.
  • Participants must have reported regular training of the bench press or chest press variation at least once weekly during the three-month period prior to screening.
  • Female participants will be required to bench press ≥ 0.5 x body mass and leg press ≥ 1.75 x body mass during initial 1RM assessments to be eligible for this study.
  • Male participants will be required to bench press ≥ 1.0 x body mass and leg press ≥ 3.0 x body mass to be eligible.
  • Regular caffeine consumption (due to the presence of caffeine in the commercially available dietary supplement). This will be defined as an average self-reported daily intake of 250+ mg of caffeine, which is equivalent to approximately 2.5 cups of coffee.

Exclusion criteria

  • Failing to meet any of the aforementioned inclusion criteria.
  • Pregnant or breastfeeding (for female participants)
  • Taking prescription medication which could reasonably make participation unsafe for the participant or influence study outcomes
  • An inability to complete resistance exercise due to injury or medical condition
  • Self-reported caffeine sensitivity, as indicated by unwanted side effects when caffeine is consumed.
  • Allergy to any of the ingredients in the test beverages or standardized breakfast.
  • Current use of anabolic steroids
  • Presence of a pacemaker or other implanted electrical device.
  • Unwillingness to wear the provided surgical mask during all testing procedures.

Treatment and study plan

Caffeinated pre-workout supplement

Dietary Supplement

The intervention will consist of consuming a standardized meal followed by one serving of the commercially available Pulse caffeinated pre-workout supplement (Legion Athletics, Inc.).

Other names: Legion Athletics Pulse Pre-workout Supplement

Non-caffeinated pre-workout supplement

Dietary Supplement

The intervention will consist of consuming a standardized meal followed by one serving of the commercially available Pulse non-caffeinated pre-workout supplement (Legion Athletics, Inc.).

Other names: Legion Athletics Pulse Pre-workout Supplement

Placebo

Dietary Supplement

The intervention will consist of consuming a standardized meal followed by a placebo beverage.

Primary outcomes

  1. Isometric Peak Force Production

    Time frame: Approximately 35 minutes after beverage ingestion in each condition.

    Peak isometric force produced on a mechanical squat device at an 120-degree knee angle.

  2. Isometric Rate of Force Development

    Time frame: Approximately 35 minutes after beverage ingestion in each condition.

    Rate of force development produced on a mechanical squat device at an 120-degree knee angle.

  3. Isokinetic Peak Concentric Force Production

    Time frame: Approximately 40 minutes after beverage ingestion in each condition.

    Peak concentric force produced during isokinetic testing on a mechanical squat device.

  4. Isokinetic Peak Eccentric Force Production

    Time frame: Approximately 40 minutes after beverage ingestion in each condition.

    Peak eccentric force produced during isokinetic testing on a mechanical squat device.

  5. Maximal Strength on Bench Press Exercise

    Time frame: Approximately 65 minutes after beverage ingestion in each condition.

    One-repetition maximum for the barbell bench press exercise.

  6. Muscular Endurance on Bench Press Exercise

    Time frame: Approximately 70 minutes after beverage ingestion in each condition.

    Repetitions to failure on the bench press exercise, using a load corresponding to 0.4 times body mass for females and 0.75 times body mass for males.

  7. Maximal Strength on Leg Press Exercise

    Time frame: Approximately 95 minutes after beverage ingestion in each condition.

    One-repetition maximum for the plate-loaded leg press exercise.

  8. Muscular Endurance on Leg Press Exercise

    Time frame: Approximately 100 minutes after beverage ingestion in each condition.

    Repetitions to failure on the leg press exercise, using a load corresponding to 1.5 times body mass for females and 2.5 times body mass for males.

Secondary outcomes

  1. Subjective Ratings of Energy

    Time frame: Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.

    Subjective rating of energy as indicated by visual analog scale (0 to 100, with a higher value indicating a higher rating of energy).

  2. Subjective Ratings of Focus

    Time frame: Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.

    Subjective rating of focus as indicated by visual analog scale (0 to 100, with a higher value indicating a higher rating of focus).

  3. Subjective Ratings of Fatigue

    Time frame: Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.

    Subjective rating of fatigue as indicated by visual analog scale (0 to 100, with a higher value indicating a higher rating of fatigue).

Other outcomes

  1. Participant Identification of Beverage

    Time frame: At the very end of each condition (i.e., approximately 105 minutes after beverage ingestion in each condition; exact time of assessment may vary based on duration of exercise performance testing for each participant).

    At the end of each exercise session (i.e., after leg press testing has concluded), participants will be asked to identify the test beverage they believe they received.

Sponsors and collaborators

Lead sponsor

Texas Tech University

Other

Collaborators

  • Legion Athletics, Inc

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jan 15, 2021
Registry last updated
Jun 3, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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