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Completed

NCT Number: NCT07573020

Influence of Acellular Dermal Matrix on Peri-implant Soft Tissue Phenotype and Marginal Bone Loss

To evaluate soft tissue augmentation using acellular dermal matrix (ADM) over immediately placed dental implants in anterior maxilla.

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Key information

Conditions

Immediate Dental Implant Placement Acellular Dermal Matrix Dental Implant Polytetrafluoroethylene Soft Tissue Augmentation at Dental Implants

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry - Mansoura University

Al Mansurah, Egypt

About this study

This randomized clinical trial was designed to evaluate and compare the efficacy of ADM versus d-PTFE membranes in the preservation of the peri-implant hard and soft tissues in the setting of immediate implant placement on the anterior maxilla.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with non-restorable maxillary anterior tooth/teeth.
  • Good oral hygiene.
  • Patients' cooperation and fully capable to comply with the study protocol.
  • Age ranges from 18 to 45 years.
  • Free from history of parafunctional habits e.g. clenching and bruxism
  • Sufficient inter- arch space.

Exclusion criteria

  • Any local pathological condition that contraindicates implant placement.
  • Pregnancy.
  • Medication that affects bone healing.
  • Psychological problems.
  • Patient had undergone radiation therapy to the head and neck area in the past 12 months.

Treatment and study plan

Polytetrafluoroethylene coverage

Procedure

The socket with immediately placed dental implant was covered with a d-PTFE membrane cut to fit the surgical site

acellular dermal matrix

Procedure

The socket with immediately placed dental implant was covered with ADM that was inserted into facial and palatal split thickness pouches.

Primary outcomes

  1. Peri-implant soft-tissue phenotype

    Time frame: Six months following implant placement

    A standardized periodontal probe was used to clinically measure the keratinized mucosal width, supracrestal tissue height, and mucosal thickness. They were measured in millimeters (mm)

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Influence of Acellular Dermal Matrix on Peri-implant Soft Tissue Phenotype and Marginal Bone Loss Following Immediate Implant Placement in Anterior Maxilla: A Randomized Controlled Clinical Trial

Acronym: ADM

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
May 7, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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