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NCT Number: NCT06920186

Infiltration or Nerve Blocks in Addition to Adductor Canal Block

The aim of this study is to evaluate the analgesic efficacy of this quadruple sensory block compared with the currently recommended procedure (adductor canal block + infiltration).

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Privé Claude Galien, Quincy-sous-Sénart, France

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About this study

In addition to the adductor canal block, this quadruple block incorporates :

  • the block of the lateral cutaneous nerve of the thigh (or femoral-cutaneous nerve), which is a collateral sensory branch of the posterior part of the lumbar plexus.
  • IPACK (Infiltration between Popliteal Artery and Capsule of Knee), designed as a motor-sparing technique (targeting the sensory articular branches of the sciatic nerve and avoiding the motor branches of the tibial and fibular nerves), is particularly effective on posterior pain.
  • obturator nerve block, a mixed nerve originating from the anterior part of the lumbar plexus. It divides into two branches: anterior, which innervates the adductor longus, adductor brevis and gracilis muscles, and posterior, which innervates the medial part of the knee joint and the posteromedial part of the thigh. It provides sensitivity to the medial aspect of the thigh.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult male or female
  • Patient with signed consent to participate in the study,
  • Patient with uni or bilateral primary gonarthrosis
  • Indication for total knee arthroplasty.

Exclusion criteria

  • History of knee fracture, arthroplasty or osteotomy
  • Known or unknown contraindication to ALR or locoregional anesthesia products
  • Neurological disease, stroke sequelae
  • Mental deficiency or any other reason that may hinder understanding or strict application of the protocol
  • Patient not affiliated to the French social security system
  • Patient under court protection, guardianship or curatorship
  • Pregnant or potentially pregnant women (women of childbearing age without effective contraception)
  • Patient already included in another therapeutic study protocol

Treatment and study plan

Analgesia

Procedure

1- Real Adductor canal block + surgical infiltration and sham of femoro-cutaneous block + obturator block + IPACK block with physiological serum

Primary outcomes

  1. Patient's recovery at H24 as after surgery assessed by the QoR-15 (Quality of Recovery) questionnaire score

    Time frame: From enrollement to the last H24 after surgery

    The QoR-15 score at H24 after surgery was compared between the two groups for primary endpoint analysis.

    The QoR-15 accurately measures postoperative recovery by focusing on 5 key domains: pain, physical comfort, physical independence, psychological support and emotional state. Each item is rated from 0 (unfavorable) to 10 (favorable), with an overall score corresponding to the sum of the score obtained for each item, i.e. a score from 0 (no recovery) to 150 (full recovery).

Secondary outcomes

  1. Knee functional assessment

    Time frame: Hour 0

    Functional assessment of the knee with KOOS JR questionnaire

  2. Post operative pain

    Time frame: Hour 2

    Pain measured with a simple numeric scale

  3. Post operative pain

    Time frame: Hour 6

    Pain measured with a simple numeric scale

  4. Post operative pain

    Time frame: Hour 12

    Pain measured with a simple numeric scale

  5. First ambulation

    Time frame: Hour 12

    time between end of intervention and first ambulation

  6. Post operative pain

    Time frame: Hour 24

    Pain measured with a simple numeric scale

  7. Joint range of both knees

    Time frame: Hour 24

    Measurement of the joint range of both knees

  8. First ambulation

    Time frame: Hour 24

    time between end of intervention and first ambulation

  9. Post operative pain

    Time frame: Hour 48

    Pain measured with a simple numeric scale

  10. Quality of recovery

    Time frame: Hour 48

    Quality of recovery measured with QoR 15 questionnaire

  11. Opioid drug use

    Time frame: Hour 48

    Opioid drug use evaluation

  12. Non-opioid drug use

    Time frame: Hour 48

    Non-opioid drug use evaluation

  13. Joint range of both knees

    Time frame: Hour 48

    Measurement of the joint range of both knees

  14. First ambulation

    Time frame: Hour 48

    time between end of intervention and first ambulation

  15. Length of stay in the post-intervention monitoring room

    Time frame: Hour 48

    Length of stay in the post-intervention monitoring room

  16. Post operative pain

    Time frame: Month 1

    Pain measured with a simple numeric scale

  17. Joint range of both knees

    Time frame: Month 1

    Measurement of the joint range of both knees

  18. Length of hospitalisation

    Time frame: Month 1

    Length of hospitalisation

  19. Return to patient usual activities

    Time frame: Month 1

    Time taken for the patient to return to their usual activities

  20. Drug tolerance

    Time frame: Month 1

    Drug tolerance

  21. Patient comfort

    Time frame: Hour 1

    Patient comfort during loco-regional anesthesia

  22. Knee functional assessment

    Time frame: Month 1

    Functional assessment of the knee with KOOS JR questionnaire

Sponsors and collaborators

Lead sponsor

GCS Ramsay Santé pour l'Enseignement et la Recherche

Other

Registry information

Official study title

Comparison of the Benefit of Peripheral Nerve Quadri-block Versus Adductor Canal Block + Surgical Infiltration in Total Knee Arthroplasty

Acronym: INCA

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 9, 2025
Registry last updated
Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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