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NCT Number: NCT05487053

The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients.

Femoral nerve block (FNB) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling.

Adductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle.

The possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Hospital on Yauza

Moscow, 111033, Russia

Location status: Recruiting

Location contact

Levan Berikashvili, PhD

CONTACT

[email protected]

+79263308968

Levan Berikashvili, PhD

PRINCIPAL_INVESTIGATOR

Sergey Stepanenko

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18
  • Planned primary total knee replacement
  • Planned neuraxial anesthesia
  • Written informed consent

Exclusion criteria

  • Urgent surgery
  • Planned revision total knee replacement
  • Known allergic reaction to anesthetics
  • Confirmed localized infection at the puncture sites
  • Confirmed localized tumor at the puncture sites
  • Peripheral neuropathy of the lower extremities
  • Parkinson's disease
  • Previously enrolled in this trial

Treatment and study plan

single-shot adductor canal block

Procedure

Postoperative analgesia in this group will be carried out by a single-shot bolus of 20 ml Ropivacaine 0.5% in the region of the middle third of the adductor canal.

Continuous femoral nerve block

Procedure

Postoperative analgesia in this group will be carried out by continuous infusion of local anesthetics through a catheter installed to the femoral nerve in the area of the femoral triangle. Ropivacaine 0.2% solution will be used for postoperative analgesia. Local anesthetic infusion rate is 4 ml/h to 10 ml/h.

Primary outcomes

  1. Ambulation distance

    Time frame: postoperative day 1

    Less meters means worse outcome

Secondary outcomes

  1. Ambulation distance

    Time frame: postoperative day 2

    Less meters means worse outcome

  2. Timed up and go test

    Time frame: postoperative day 1

    More seconds means worse outcome

  3. Timed up and go test

    Time frame: postoperative day 2

    More seconds means worse outcome

  4. 10 meters walk test

    Time frame: postoperative day 1

    More seconds means worse outcome

  5. 10 meters walk test

    Time frame: postoperative day 2

    More seconds means worse outcome

  6. 30 seconds chair stand test

    Time frame: postoperative day 1

    Less exercise done means worse outcome

  7. 30 seconds chair stand test

    Time frame: postoperative day 2

    Less exercise done means worse outcome

  8. 5 times sit to stand test

    Time frame: postoperative day 1

    More seconds means worse outcome

  9. 5 times sit to stand test

    Time frame: postoperative day 2

    More seconds means worse outcome

  10. time to readiness to dicharge

    Time frame: 30 day

    time from the day of surgery to the day of readiness to discharge

  11. length of hospitalization

    Time frame: 30 day

    time from the day of surgery to the day of discharge

Other outcomes

  1. intravascular local anesthetic injection

    Time frame: 30 day

    frequency of intravascular local anesthetic injection

  2. neuropathy after the procedure

    Time frame: 30 day

    frequency of neuropathy after the procedure

Study contacts

Contact information is provided by the study sponsor or research team.

Levan Berikashvili

CONTACT

[email protected]

+79263308968

Valery Likhvantsev

CONTACT

[email protected]

+79036235982

Sponsors and collaborators

Lead sponsor

Negovsky Reanimatology Research Institute

Other Gov

Registry information

Official study title

The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement (AdORe - ACB)

Important dates

Study start
2024
Primary completion
2027
Study completion
2028
First posted
Aug 4, 2022
Registry last updated
Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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