Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study

Introduction. Comprehensive data on infective endocarditis in developing countries are scarce.

Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis in low-income countries.

Methods : Prospective, Observational, Multicentre study. Inclusion criteria: patients aged over 1 year fulfilling the modified Duke criteria for infective endocarditis.

Exclusion criteria: patient included during a previous infective endocarditis episode.

Outcomes measures: Mortality at 6 months follow-up; mortality at 1 month follow-up; access to antibiotic treatment (modalities and duration), hospital length of stay and reason for discharge, and cardiac surgery when indicated.

Duration: One year (June 2014- June 2015)

Completed

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Key information

Conditions

Infective Endocarditis Bacteremia Bacterial Infections Bacterial Infections and Mycoses Cardiovascular Diseases Endocarditis Heart Diseases Heart Valve Diseases Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

1 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Joseph Kado, Suva, Fiji

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged over 1 year diagnosed with infective endocarditis according to the modified Duke criteria

Exclusion criteria

Already included for a previous episode of infective endocarditis (i.e., relapse or reinfection)

Treatment and study plan

Primary outcomes

Mortality at 1 month follow-up

Time frame: 1 month

Secondary outcomes

Mortality at 6 months follow-up

Time frame: 6 months

Other outcomes

Access to cardiac surgery

Time frame: 6 months

Heart surgery is not available in many low-income countries. One of the objectives is to assess whether guidelines can be applied in low-secourced settings.

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Collaborators

Bafoussam Regional Hospital, Cameroon
CHR de Saint-Louis Lt Colonel Mamadou Diouf, Sénégal
CHU de Brazzaville, Congo Brazzaville
Centers for Disease Control and Prevention
Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou, Benin
Eduardo Mondlane University
Fann Hospital, Senegal
Hospital General De Douala
Hospital Laquinitinie de Douala
Hôpital Général de Grand Yoff de Dakar, Sénégal
Institute of Cardiology Abidjan
Laos Oxford Mahosot Wellcome Research Unit
Mulago Hospital, Uganda
National Hospital of Niamey
Oxford University Hospitals NHS Trust
Polyclinique International de Bamako, Mali
St. Elizabeth Catholic General Hospital Shisong, Cameroun
War Memorial Hospital
Yaounde Central Hospital

Registry information

Acronym: EndoDev

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: May 1, 2014
Registry last updated: May 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed