Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3

In the interventional arm (no-echocardiography strategy) without echocardiography, at the individual level, not performing an echocardiography will avoid a useless examination, the mobilization of the patient and the discomfort related to its performance.

In this arm, the theoretical risk is to diagnose Infective endocarditis (IE ) only at a later phase stage, i.e., at a phase of symptomatic manifestation of valve regurgitation or at the occurrence of relapse of bacteremia due to insufficient duration of antibiotic treatment. It should be noted that patients with prosthetic valve, who have "de facto" a VIRSTA score > 3, will therefore not be included in the protocol. Given the expected rarity of IE in patients with a VIRSTA score <3 and the theoretical consequences of not performing echocardiography, the primary endpoint chosen will be mortality and Staphylococcus aureus bacteraemia (SAB) relapse. The endpoint will be assessed at 90 days and not at discharge to capture relapses of inadequately treated bacteremia and the mid-term consequences of a possible delay in IE diagnosis.

On a collective scale, not performing echocardiography in many patients in whom it is not useful will allow resources to be allocated to the individuals who need it most.

Inclusion criteria

• Volunteers over 18 years of age;
• Hospitalized with at least one blood culture positive for Staphylococcus aureus;
• At the time of inclusion, negative control blood culture performed 48 hours after the first Staphylococcus aureus blood culture collection;
• VIRSTA score < 3; Exclusion criteria
• Patient with catheter colonization without SAB, defined as positive blood cultures only through vascular access device specimen;
• Patient referred to the hospital for the management of IE;
• Contra indication to transthoracic echocardiography (TTE);
• Echocardiography already performed before inclusion (TTE or TEE) for the current SAB;
• Pregnancy;
• Patient under guardianship or trusteeship.
• Absence of written informed consent from the patient
• No affiliation to social security (beneficiary or assignee)
• Subject already involved in another interventional clinical research for which echocardiography must be done"