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NCT Number: NCT02080065

Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Liver Transplantation

The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but preoperative medication and intraoperative colloid administration and hemodynamic parameters have not been evaluated. Therefore, we attempt to evaluate perioperative risk factors and develop simplified clinical risk scoring model.

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Key information

Conditions

Renal Function Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Liver Transplantation Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung Medical Center

Seoul, 135-710, South Korea

About this study

Ischemia/reperfusion injury occurs during graft harvesting, cold storage, and surgical procedures in liver transplantation. Ischemia/reperfusion injury in liver graft results in major organ damage including kidney, lung and heart as well as graft dysfunction. Graft dysfunction and renal injury after liver transplantation are major clinical issues and are associated with prognosis and low survival rate. The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but perioperative medication, metabolic variables (albumin, glucose, uric acid), intraoperative colloid administration and hemodynamic parameters have not been evaluated. In addition, a neutrophil-lymphocyte ratio (NLR), which has been reported to be related to systemic inflammation and associated with prognosis of cardiac and cancer patients, might be related to the development of AKI after LDLT. Therefore, we attempt to evaluate these perioperative risk factors and develop simplified clinical risk scoring model.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent living donor liver transplantation between 2010 and 2013 in Samsung Medical Center

Exclusion criteria

  • Incomplete data regarding pre- and postoperative creatinine and estimated Glomerular Filtration Rate
  • patient who underwent retransplantation

Treatment and study plan

Living donor liver transplantation

Procedure

Primary outcomes

  1. acute kidney injury as defined by RIFLE criteria

    Time frame: during 7 days after transplantation

    acute kidney injury as defined by RIFLE criteria

Secondary outcomes

  1. incidence of renal replacement therapy

    Time frame: during one month after transplantation

    renal replacement therapy

  2. incidence of acute rejection of graft

    Time frame: during one month after transplantation

    incidence of acute rejection of graft

  3. incidence of initial poor graft function

    Time frame: during one month after transplantation

    incidence of initial poor graft function

  4. incidence of retransplantation

    Time frame: during one month after transplantation

    incidence of retransplantation

Other outcomes

  1. Mortality

    Time frame: during one month, six month, one year

    Mortality during one month, six month, one year

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Mar 6, 2014
Registry last updated
Aug 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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