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Completed

NCT Number: NCT07059559

Rhythmic Walking Program and Renal Function and Oxidative Stress

This study designed a over-knee automatic step counter device. Then, we evaluated its efficacy on renal function and oxidative stress in patients with chronic kidney disease.

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Key information

Conditions

Renal Function

Age range

18 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rehabilitation Medicine Department, Chamni Hospital

Chamni, Changwat Buri Ram, 31110, Thailand

About this study

This study is a randomized controlled trial. Patients who consent to participate and pass the screening process will be randomly assigned to groups based on the order of their participation (random by sequence). Patients who join in odd-numbered order, such as 1st, 3rd, 5th, etc., will receive standard care as provided by the hospital (control group). Patients who join in even-numbered order, such as 2nd, 4th, 6th, etc., will receive a walking program. This involves continuous walking exercise for 30 minutes, once a day, three days a week, over a period of three months. During the walking sessions, patients will walk at a pace of 60 steps per minute, or one step per second.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female
  • Aged between 18 and 59 years
  • Diagnosed by a physician with chronic kidney disease stage 2-4, with a glomerular filtration rate (GFR) between 15-89 milliliters per minute, persisting for at least 3 months

Exclusion criteria

  • No musculoskeletal disorders that hinder walking, such as osteoarthritis
  • Not engaging in regular exercise (less than 3 times per week or less than 150 minutes per week)
  • Not regularly taking medications or supplements containing antioxidants

Treatment and study plan

Rhythmic walking

Other

Patients who consent to participate and pass the screening process were randomly assigned to groups based on the order of their participation (random by sequence): control group or rhythmic walking group.

Primary outcomes

  1. Creatinine level

    Time frame: Day 0 and day 91

    Blood creatinine level was measured in mg/dL unit

  2. Malondialdehyde level

    Time frame: Day 0 and day 91

    Blood malondialdehyde level was measured in micromolar unit

  3. Superoxide dismutase activity level

    Time frame: Day 0 and day 91

    Blood superoxide dismutase activity level was measured in percent unit

  4. Estimated glomerular filtration rate level

    Time frame: Day 0 and day 91

    Estimated glomerular filtration rate level was measured in ml/min/1.73 m2 unit

  5. Estimated creatinine clearance level

    Time frame: Day 0 and day 91

    Estimated creatinine clearance level was measured in ml/min unit

Sponsors and collaborators

Lead sponsor

Burapha University

Other

Registry information

Official study title

Efficacy of Rhythmic Walking Program on Renal Function and Oxidative Stress in Subjects With Chronic Kidney Disease

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 11, 2025
Registry last updated
Jul 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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