UCSD Eating Disorders Treatment and Research Program
La Jolla, California, 92121, United States
Location status: Recruiting
Location contact
Christina Wierenga
PRINCIPAL_INVESTIGATOR
Katherine Gandee
CONTACT
Megan Martinho
CONTACT
NCT Number: NCT05056597
The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39.
Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC.
Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC.
Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later.
Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.
Interested in participating?
Request Info18 year–39 year
Female
Observational
La Jolla, California, 92121, United States
Location status: Recruiting
Christina Wierenga
PRINCIPAL_INVESTIGATOR
Katherine Gandee
CONTACT
Megan Martinho
CONTACT
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Eating Disorder Group:
Healthy Control Group:
Exclusion criteria
All Groups:
Additional Exclusion Criteria for ED Group:
-If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning
Additional Exclusion Criteria for Healthy Control Group:
Time frame: 1 Year
Brain activity associated with 'liking', 'wanting', and learning
Time frame: 1 Year
Task reinforcement learning rate in reward and punishment trials
Time frame: 1 Year
Functional connectivity maps from task-based fMRI data and clinical data
Contact information is provided by the study sponsor or research team.
University of California, San Diego
Other
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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