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OpenTrials
Completed

NCT Number: NCT02841852

Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients?

Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drugs in the world and the most effective drugs available to reduce gastric acid secretion. However, studies have shown that PPIs are not always prescribed with a clear indication. Indeed, between 25% and 86% of older individuals taking a PPI have been overprescribed these medications. In older patients, overprescribing of a PPI is associated with increases in morbidity, adverse drug events, hospitalization, and mortality. The hypothesis is that overprescription of PPIs is associated with the individual multimorbidities in older patients evaluated using the multimorbidities group criteria included in the CIRS. The aim of the present study was to establish a relationship between overprescribing of PPIs and multimorbidities in older patients.

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Key information

Conditions

Geriatric Disorder

Age range

75 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier de St Nazaire

Saint-Nazaire, 44606, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of 75 years or more
  • Patients hospitalized in geriatric short stay
  • Patients with an inhibitor therapy proton pump short geriatric entry
  • Patients who have given their written consent

Exclusion criteria

  • Patients who have expressed their inability or refusal to sign an informed consent

Treatment and study plan

Primary outcomes

  1. Burden of comorbidities

    Time frame: 48 hours after the entry into acute geriatric medicine

    Burden of comorbidities is assessed by the CIRS (Cumulative Illness Rating Scale)

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients Over 75 Years Old ?

Acronym: IPP SA

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jul 22, 2016
Registry last updated
Jul 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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