In Vitro Maturation of Human Eggs

Patients will undergo a complete IVF workup to qualify for study. Once passing their baseline appointment patients will undergo a three day low dose stimulation followed by egg retrieval 18-22 hours post last medication dosage. Immature oocytes will be retrieved from the ovaries via ultrasound guided TV aspiration and matured overnight in the laboratory. Mature oocytes will be fertilized via ICSI the following day and cultured to the blastocyst stage. Biopsy of the first 14 blastocysts are included with this package, patients have the option biopsy additional embryos if available. Biopsies will be sent for PGTA testing. This study also includes preparation for and the first frozen embryo transfer. Some FET medication is included as well as testing through the first pregnancy test.

Inclusion criteria

• Infertile women diagnosed with PCOS or polycystic ovaries, or infertile women with good ovarian reserve
• Antral follicle count (AFC) greater than 24
• AMH greater than 3.5 ng/ml
• Body Mass Index less than 35
• Accept to have embryos biopsied for PGT
• Intend to perform embryo transfer within 4 months after completing the IVM cycle
• Paternal (or donor) age <45, ejaculated sperm collection only (partner frozen and donor sperm acceptable), sperm morphology (strict criteria) >1%, motility > 20% and sperm count > 10 million per ml (so samples can be prepared through standard procedure)

Exclusion criteria

• More than 2 failed IVF cycles