Impulsivity and Time Perception

Cannabis smokers having begun prematurely their consumption (before 16 years) present a persistent impulsivity much later after have stopped their consumptions. The literature highlights that the impulsivity promotes the passage towards a compulsive consumption, and the loss of control. To explain this phenomenon, some authors hypothesized that impulsivity would lead the subjects to overestimate the duration of events and to choose immediate rewards than preferred but delayed rewards. This hypothesis questions the role of the temporal anticipation in the impulsive choices. In a first hypothesis, the temporal impulsivity could be an endogenous deficit bound to the reward, and would be responsible for disorders of the temporal anticipation. In this case, the disorders should be observed especially when the subject anticipates a reward. Alternately, a disorder of the temporal anticipation could provoke impulsivity, and in this case, would be present with or without reward. To separate these hypotheses, we propose to test the capacities of temporal anticipation of non-smokers and early smokers of cannabis by means of a behavioral task " Hazard function task ", which allow to measure the capacity of a subject to anticipate the apparition of an event on the basis of a temporal cue. The neuronal correlates will be measured by a recording EEG of the wave ' CNV ' (fix a quota for denial of variation) which reflects the temporal accumulation and the processes of anticipation.

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Key information

Conditions

Cannabis Use Behavior Behavior, Addictive Compulsive Behavior Impulsive Behavior

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Les Hôpitaux Universitaires de Strasbourg

Strasbourg, Alsace, 67091, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteers Man or woman of age between 18 and 50 years-old
Absence of consumption of cannabis and tobacco for 1 year and absence of substance use disorder in history
Matching in age and sex to the group consumers of cannabis
Early consumers of cannabis (at the beginning of the consumptions before 16 years)
Man or woman of age between 18 and 50 years old
Statement of more than three consumptions a day of cannabis for at least one year and consumption of cannabis having begun before the age of 16 years.
Urinary analysis is positive for the presence of cannabis
Positive auto-questionnaire CAST: 2 positive answers to CAST questionnaire
Hospitalized or not

Exclusion criteria

Presence or history of a severe and invalidating somatic pathology (neurological, cardiovascular, lung, metabolic, renal, hepatic, gastro-intestinal)

History of cranial trauma with loss of consciousness.
substance use disorder except the substance tested in the protocol (cannabis).
Invalidating sensory disorders in particular visual: glaucoma, any retinal pathology. Visual acuteness 0.8
History of general anesthesia in the previous 3 months the study
Any evolutionary neurological or psychiatric pathology
Subject under guardianship
pregnancy
Feeding

Treatment and study plan

Primary outcomes

Measure the capacities of the subjects to anticipate the apparition of the target

Time frame: 8 days after inclusion in the study

on the basis of a temporal cue presented before the target, and give the response as quickly as possible after the presentation of a rewarding versus not rewarding target.

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Link Between Impulsivity and Time Anticipation

Important dates

Study start: 2017
Primary completion: 2020
Study completion: 2020
First posted: May 22, 2017
Registry last updated: Aug 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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