Impulse Control in Gilles de la Tourette Syndrome

The study intends to evaluate the role of Mirror Neurons in the determination of gestures, words, and repetitive vocalizations in subjects affected by Tourette's syndrome and to verify if these subjects are faster to assemble sounds, in phonology and morphology, than the non-pathological population.

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Key information

Conditions

Tourette Syndrome Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Heredodegenerative Disorders, Nervous System Mental Disorders Movement Disorders Nervous System Diseases Neurodegenerative Diseases Neurodevelopmental Disorders Tic Disorders

Age range

6 year–10 year

Sex eligibility

All sexes

Study type

Observational

Primary location

IRCCS Istituto Ortopedico Galeazzi

Milan, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

TOURETTE GROUP

Consecutive patients belonging to the Tourette Center
Caucasian
Italian mother-tongue
Age between 6 and 10 years completed
Male and female 4: 1 (16 males and 4 females)
Diagnosis of Tourette's syndrome for at least 1 year
Presence of a value of YGTSS> 50%

NOT GROUP TOURETTE

Caucasian
Italian mother-tongue
Age between 6 and 10 years completed
Male and female 4: 1 (16 males and 4 females)

Exclusion criteria

TOURETTE GROUP

Diagnosis of DSA
Presence of significant psychiatric disorders, with the exception of those belonging to the Tourette Syndrome itself (eg ADHD, OCD).

NOT GROUP TOURETTE

Diagnosis of DSA
Presence of significant psychiatric disorders

Treatment and study plan

Routine tests perform

Other

The subjects of the Tourette group and control group are subjected to routine tests performed at Tourette Center and Extrapyramidal Diseases. Both groups are initially subjected to an evaluation that aims to identify the IQ and therefore 4 tasks are presented. The 1st (with a duration of about 2 and a half minutes) and the 2nd (with a duration of about 2 minutes) related to the motor field, the 3rd (with duration of about 1 minute) and the 4th (with duration about 3 minutes) the language field. These evaluations are in practice at the Center for Tourette patients; the tasks will be administered to both groups.

Primary outcomes

Tourette syndrome and the imitation of gestures

Time frame: Through study completion, an average of 1 year

The aim is to investigate the correlation between Mirror Neurons and Tourette Syndrome defining the greater propensity of the Tourettian subjects to imitate gestures, through the administration of the first Task

Sponsors and collaborators

Lead sponsor

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Other

Registry information

Official study title

Do Mirror Neurons Play a Role in Tourette Syndrome Physiopathology? A Pilot Study.

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Dec 13, 2019
Registry last updated: May 9, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed