Improving Mothers for a Better PrenAtal Care Trial Barcelona

Randomized controlled trial among women at higher risk to have a growth restricted fetus (30%) according to Royal College of Obstetrics and Gynecology (RCOG) Guidelines. These high-risk women will be randomized in order to evaluate an improvement in several outcomes thanks to different strategies applied to the mothers: a stress reduction program based on mindfulness techniques or a nutrition interventional program based on Mediterranean diet.

Main hypothesis: specific interventions improving maternal lifestyle and well being have a positive impact on pregnancy outcomes as well as on fetal growth and development.

Secondary hypothesis is that interventions to improve maternal lifestyle well being have a positive impact on offspring's outcome later in life, in terms of neurodevelopment and cardiovascular profile, mediated by epigenetic changes in offspring.

Inclusion criteria

• Maternal age at recruitment ≥18 years
• Speak Spanish fluently
• Viable singleton non-malformed fetus
• High-risk pregnancy to develop FGR.
• 19-23 weeks of gestation

Exclusion criteria

• Fetal anomalies including chromosomal abnormalities or structural malformations detected by ultrasound.
• Mental retardation or other mental or psychiatric disorders that impose doubts regarding the true patient´s willingness to participate in the study.
• No possibility to come to additional visits.