Improving Bladder Function in SCI by Neuromodulation

This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury. Neuromodulation will be in the form of transcutaneous electrical stimulation and/or magnetic stimulation.

Inclusion criteria

• Male 18-45 years;
• At least 1 year post-injury;
• Non-progressive SCI at C2-T8 (non-conus injury);
• Motor Complete ASIA (A or B);
• Neurogenic bladder requiring clean intermittent straight catheterization;
• Able to attend twice weekly testing sessions for 6 months.
• Have intact lower extremity anatomy and able to use lower extremity for assistive standing and stepping.

Exclusion criteria

• History of autonomic dysreflexia;
• Ventilator dependency;
• Musculoskeletal dysfunction, unhealed fracture, pressure ulcer, active infection;
• Clinically significant depression or ongoing drug abuse;
• Received botox injection, or bladder surgery (suprapubic access, Brindley procedure, etc.); 6. Prostatic hypertrophy or bladder outlet disorder;

• Cardiopulmonary disease that precludes lower extremity training or rehabilitation.