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NCT Number: NCT05325736

Improvement in Glycemic Response After Bariatric Surgery

decipher the role of microbiota in glycemic response change after bariatric surgery

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Key information

Conditions

Bariatric Surgery

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Weizmann Institute of Science, Rehovot, Israel

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About this study

Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks.

Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations.

The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • candidates of bariatric surgery or cholecystectomy
  • age 18-70
  • male/female

Exclusion criteria

  • previous bariatric surgery
  • type 1 diabetes
  • antibiotic treatment 3 months prior to the study
  • probiotic treatment 3 months prior to the study
  • chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
  • any pathologic findings during endoscopy
  • participants who will suffer from a post-operation complication

Treatment and study plan

sleeve gastrectomy surgery

Procedure

participants undergoing sleeve gastrectomy surgery

Gastric bypass surgery

Procedure

participants undergoing gastric bypass surgery

Control

Procedure

cholecystectomy

Pancreatectomy

Procedure

Collecting a sample of an unidentified healthy pancreas to extract insulin-secreting beta cells from the sample

Primary outcomes

  1. Glycemic response

    Time frame: up to 4 years

    The glycemic response will be measured by taking a blood test (glucose) after 12 hours fast and a second blood test (glucose) after an OGTT(oral glucose tolerance test) of 50 g glucose

  2. microbiota composition

    Time frame: up to 4 years

    The microbiota composition will be assessed using the stool samples of the participants.

Study contacts

Contact information is provided by the study sponsor or research team.

Avner Leshem, MD

CONTACT

[email protected]

+972547487555

Sponsors and collaborators

Lead sponsor

Weizmann Institute of Science

Other

Collaborators

  • Tel-Aviv Sourasky Medical Center

Registry information

Important dates

Study start
2021
Primary completion
2028
Study completion
2029
First posted
Apr 13, 2022
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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