Improve Medication Adherence Among Stroke Survivors in Rural Kentucky

To test the feasibility and promise of a combined intervention provided by community health worker (CHW) in collaboration with pharmacy technician and pharmacist to improve hypertension and long-term stroke outcomes by identifying and reducing barriers to medication adherence among ischemic stroke survivors. This collaborative intervention involves a self-management program including an educational session on practical strategies to improve hypertension control (i.e., appropriately taking medications, necessity of treatment, and consequences of not taking medicine, etc.), complemented by individually-tailored sessions to identify and address barriers to medication adherence.

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Key information

Conditions

Stroke (CVA) or Transient Ischemic Attack Brain Diseases Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Attack, Transient Nervous System Diseases Stroke Vascular Diseases

Age range

30 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Kentucky

Lexington, Kentucky, 40356, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients with history of ischemic stroke or transient ischemic attack (TIA) in the past 2 years
residing in a rural county in Kentucky

Exclusion criteria

significant aphasia
cognitive impairment
a terminal illness
other neurologic deficits that would impede from providing informed consent or meaningfully participate in the one-to-one sessions.
a prior aneurysmal subarachnoid hemorrhage and or aneurysm, cerebral venous sinus thrombosis, vasculitis, blood clotting disorder due to genetic causes
if the patient does not take any secondary preventative medications

Treatment and study plan

I-MAS

Behavioral

Participants will receive a one-to one session with the pharmacy technician that involves two parts; the first part include education on ischemic stroke and risk factors such as practical strategies to improve hypertension control (i.e., appropriately taking medications, necessity of treatment, and consequences of not taking medicine, etc., making healthier dietary choices, exercising regularly, smoking cessation, alcohol intake, and managing blood sugar. The second part involves an interview to collect information on socio-demographics, clinical factors, co-morbidities, medications, and medication adherence barriers. During the second part of the session, the pharmacy technician will identify barriers to medication adherence for secondary prevention of stroke medications including antihypertensives, antithrombotic agents, and statins. The pharmacist will collaborate with the pharmacy technician to develop an action plan to address medication adherence barriers

Other names: Improve Medication Adherence Among Stroke Survivors

Primary outcomes

Change in Medication Adherence Questionnaire

Time frame: Baseline and at 3 months

Medication adherence is measured using a 12-item questionnaire that determines how often medications are missed. Scores range from 12 to 48 with lower scores indicating better adherence

Sponsors and collaborators

Lead sponsor

Hend Mansoor

Other

Collaborators

National Institute on Minority Health and Health Disparities (NIMHD)

Registry information

Official study title

Intervention to Improve Medication Adherence Among Stroke Survivors in Rural Kentucky

Acronym: I-MAS

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jul 24, 2025
Registry last updated: Jan 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed