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NCT Number: NCT07134686

Implementation of a Joint Pulmonologist and ENT Consultation in the Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations by Specialty (CON-PO Study).

Asthma affects the lower respiratory tract (bronchi), whereas chronic rhinosinusitis with nasal polyposis (CRSwNP) involves the upper airways. Despite this anatomical distinction, the upper and lower airways form a continuous respiratory tract and share common pathophysiological mechanisms. Consequently, asthma and CRSwNP frequently coexist, and several therapeutic strategies are effective for both conditions.

Given these overlaps, we hypothesize that a multidisciplinary consultation involving both a pulmonologist and an ENT specialist could be more effective than separate consultations for patient care. We also believe that this innovative organization that would benefit the healthcare system.

To test this hypothesis, we are conducting a study whose primary objective is to assess whether joint consultations lead to a reduction in oral corticosteroid need over the year following the initial consultation, by enabling more personalized treatment strategies.

Secondary outcomes will include the frequency of asthma exacerbations, frequency of ENT-related events, respiratory symptoms, quality of life, and healthcare ressources utilization.

We will compare outcomes between two patient groups: one receiving joint consultation from both specialists, and the other managed through standard, separate consultations as per current clinical practice.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female, 18 years of age or older;
  • With a diagnosis of asthma;
  • With a diagnosis of chronic rhinosinusitis with nasal polyposis;
  • Whose asthma and/or chronic rhinosinusitis is/are not controlled according to SNOT-22 and ACQ-6 scores;
  • Having used systemic corticosteroids in the previous year to treat symptoms related to one of these conditions at least;

Exclusion criteria

  • Patient in a period of exclusion from another research protocol at the time of consent signature;
  • Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (adult patients under guardianship or curatorship, patients deprived of their liberty, pregnant or breast-feeding women);
  • Patients who do not read and/or understand French

Treatment and study plan

Joint consultation

Other

Joint consultation with pneumologist and ENT at baseline.

Mucus sampling

Procedure

Mucus sampling at baseline and one year follow-up

nasal brushing

Procedure

Nasal brushing at baseline and one year follow-up

Primary outcomes

  1. Effectiveness of joint ENT and pulmonologist consultation on relative change in cumulative annual dose of oral corticosteroids from the year before Baseline to the year between Baseline and 12 months visit.

    Time frame: From the year before Baseline to the 12 months visit.

    Self reported cumulative annual dose of oral corticosteroids.

Secondary outcomes

  1. Reduction of asthma exacerbations frequency. Relative change from the year before Baseline to the year between baseline and 12 months visit in number of asthma exacerbations.

    Time frame: From the year before Baseline to the 12 months visit.

    self-reported number of asthma exacerbations

  2. Reduction of ENT events frequency. Relative change from the year before baseline to the year between baseline and 12 month visit in number of ENT events.

    Time frame: From the year before Baseline to the 12 months visit.

    Self reported number of ENT events

  3. Improvement of asthma control. Relative change from baseline to 12 months visit in ACQ-6 score

    Time frame: Baseline and 12 months visit.

    Self-administered questionnaire

  4. Improvement of chronic rhinosinusitis with nasal polyposis control . Relative change from baseline to 12 months visit in SNOT-22 score

    Time frame: Baseline and 12 months visit.

    Self-administered questionnaire

  5. Reduction in endoscopic polyp score. Relative change from baseline to 12 months visit in the polyp endoscopic score (mean of measures of both nostrils)

    Time frame: Baseline and 12 months visit.

    Evaluated with nasal endoscopy

  6. Improvement of patient's quality of life. Relative change from baseline to 12 months visit in EQ-5D-5L score

    Time frame: Baseline and 12 months visit.

    Self-administered questionnaire

  7. Reduction of healthcare ressource use . Relative change from baseline to 12 months visit in number of consultations with a specialist, general practitionner, emergency visits and hospitalizations

    Time frame: From Baseline to the 12 months visit

    Self-reported number of consultations with a specialist, general practicionner, emergency visits and hospitalizations

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Acronym: CON-PO

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Aug 21, 2025
Registry last updated
Sep 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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