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NCT Number: NCT06993077

Impact of Ultraviolet Radiation and Environmental Factors on Human Ocular Biomechanics

This observational study aims to explore whether ultraviolet (UV) radiation and other environmental factors are associated with ocular biomechanical properties in healthy volunteers aged 18-44 years without ocular diseases, ocular surgery history, or systemic diseases.

The main questions it aims to answer are:

Is there a significant correlation between UV radiation levels and corneal biomechanical parameters?

Do environmental factors such as geographic region and seasonal variation affect corneal biomechanical behavior?

Researchers will compare ocular biomechanical parameters among populations from different geographic regions with varying levels of UV radiation to determine whether there are statistically significant correlations or differences.

Participants will:

Undergo standardized ophthalmic examinations, including visual acuity, intraocular pressure, slit-lamp evaluation, axial length, and corneal topography;

Receive corneal biomechanical assessments using the Corvis ST device;

Provide basic demographic information and medical history;

Have all data de-identified, with the study strictly following ethical approval and privacy protection protocols.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Myopia Eye Diseases Refractive Errors

Age range

18 year–44 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tianjin Eye Hospital

China, Tianjin Municipality, 300000

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion Criteria

Age between 18 and 44 years (based on WHO criteria);

Spherical equivalent refraction (SER) ≤ 6.00 diopters;

No other ocular diseases;

No systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases);

No severe psychiatric or psychological disorders;

No history of ocular surgery.

Exclusion criteria

Severe psychiatric disorders;

Individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the Global Consensus on Keratoconus Diagnosis);

Presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis);

History of intraocular or ocular surface surgeries;

Presence of nystagmus or inability to cooperate with examinations;

History of intraocular surgery;

Presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases).

Exclusion criteria

Severe psychiatric disorders;

Individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the Global Consensus on Keratoconus Diagnosis);

Presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis);

History of intraocular or ocular surface surgeries;

Presence of nystagmus or inability to cooperate with examinations;

History of intraocular surgery;

Presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases).

Treatment and study plan

environment Exposure

Other

No special intervention

Primary outcomes

Corneal Biomechanical Parameters Measured by Corvis ST

Time frame: Baseline (at time of examination)

Central corneal thickness (CCT) mm
Corneal Biomechanical Parameters Measured by Corvis ST

Time frame: Baseline (at time of examination)

,biomechanically corrected intraocular pressure (bIOP) mmHg

Sponsors and collaborators

Lead sponsor

Tianjin Eye Hospital

Other

Registry information

Official study title

Association Between Ultraviolet Radiation, Environmental Factors, and Ocular Biomechanical Properties: A Multicenter Cross-Sectional Study

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: May 28, 2025
Registry last updated: May 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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