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NCT Number: NCT06647472

Proteomic Analysis on Myopic Children Using Orthokeratology Lenses With Good or Poor Myopic Control

The key objective of the study is to gain an understanding of the biochemical processes that contribute to orthokeratology lenses being more effective in specific individuals compared to others. With this knowledge, we hope to optimize treatment effectiveness in those currently experiencing less favorable outcomes from treatment in the future.

The primary aim is to investigate differences in protein levels in children using orthokeratology lenses with various effects of myopia control.

Hypothesis: There is a significant difference in the expression of molecules in children with various effects of myopia control.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Myopia Eye Diseases Healthy Orthokeratology Refractive Errors

Age range

5 year–14 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Øjenafdelingen, Vejle Sygehus

Vejle, Denmark

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children treated with orthokeratology lenses.
  • Children on or above the 95th percentile of myopia growth curves for European children at the time of treatment initiation.
  • Treatment and follow-up duration ≥ 6 months.

Exclusion criteria

  • Current use of eye drops.
  • Objective signs of dry eyes on slit-lamp examination.
  • Active eye infection.

Treatment and study plan

Primary outcomes

  1. Difference in protein levels measured by mass spectrometry label-free quantification (LFQ) between children using orthokeratology lenses with different levels of myopia control effectiveness

    Time frame: At baseline

Sponsors and collaborators

Lead sponsor

Vejle Hospital

Other

Collaborators

  • University of Aarhus

Registry information

Official study title

Proteomic Analysis on Myopic Children Using Orthokeratology Lenses With Good or Poor Myopic Control. The ProMOC Study

Acronym: ProMOC

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Oct 17, 2024
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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