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NCT Number: NCT04281056

Impact of Tooth Loss and Denture on Oral Senses and Food Preferences

Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.

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Key information

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service odontologie Hôpital Rothschild

Paris, 75002, France

Location status: Recruiting

Location contact

Adeline Braud, Dr

CONTACT

[email protected]

01 40 19 39 87

About this study

Two groups of participants will be included. Participants wearing complete denture for at least one year (n=20) and their matched controls for age, sex, tobacco, and saliva secretion (n=20). Their oral sensory abilities of participants will be assessed including taste (electrogustometric thresholds, chemical taste identification ability) and trigeminal quantitative sensory testing. Food preferences and selectivity (Maitre et al., 2014) and taste appetence (Deglaire et al., 2012) will also be assessed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls:

controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate.

Exclusion criteria

  • Aged under 18 or over 80 Y,
  • not consenting to participate
  • suffering from dental
  • periodontal or gum pain for the last month.

Treatment and study plan

Tooth removal and their replacement by means of a denture

Procedure

Teeth have been removed and replaced by means of dentures for at least one year

Primary outcomes

  1. taste detection thresholds

    Time frame: up to 30 days

    Using an Electrogustometer

Secondary outcomes

  1. Chemical taste identification ability

    Time frame: up to 30 days

    Using taste strips (Burghard)

  2. Quantitative sensory testing

    Time frame: up to 30 days

    Using an algometer, von frey filament, a thermode.

  3. Food preferences and selectivity

    Time frame: up to 30 days

    Questionnaire food selectyivity and preference (Maitre et al., 2014)

  4. Taste appetence

    Time frame: up to 30 days

    Questionnaire PrefQuest (Deglaire et al., 2012)

Study contacts

Contact information is provided by the study sponsor or research team.

Adeline Braud, Doctor

CONTACT

[email protected]

01 40 19 39 87

Yves Boucher, Professor

CONTACT

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference

Acronym: AlimaPAC

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Feb 21, 2020
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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