Impact of tDCS on Cerebral Autoregulation

The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

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Key information

Conditions

Cerebral Microangiopathy Brain Diseases Brain Infarction Brain Ischemia CADASIL Cardiovascular Diseases Central Nervous System Diseases Cerebral Arterial Diseases Cerebral Infarction Cerebral Small Vessel Diseases Cerebrovascular Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dementia Dementia, Vascular Genetic Diseases, Inborn Headache Disorders Headache Disorders, Primary ICA Stenosis Infarction Intracranial Arterial Diseases Ischemia Migraine Disorders Migraine With Aura Necrosis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Neurology, Charité Universitätsmedizin Berlin

Berlin, State of Berlin, 10117, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

severe cerebral Microangiopathy
NOTCH3 carrier
Migraine with aura (IHS Classification ICHD-II)
Stenosis >80%, ECST-Criteria

Exclusion criteria

seizure disorder
history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity
dementia

(1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis >50%,

Treatment and study plan

Anodal tDCS

Device

Cathodal tDCS

Device

Sham tDCS

Device

Primary outcomes

Cerebral vasomotor reactivity assessed by transcranial Dopplersonography

Time frame: on 3 days within 12 weeks

comparing cerebral vasomotor reactivity at baseline and after anodal/cathodal/sham stimulation

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2014
First posted: May 31, 2013
Registry last updated: Mar 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed