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Completed

NCT Number: NCT00692848

Impact of Procalcitonin on the Management of Children Aged 1 to 36 Month Presenting With a Fever Without a Source

Serious bacterial infections are often difficult to detect in children with fever without source. Procalcitonin is a better blood marker of infection than White blood cell count and possibly than C-reactive protein. This could lead to a reduction in antibiotic prescription. Our objective is to evaluate the impact of Procalcitonin result on antibiotic prescription in children 1 to 36 month old with fever without source and our hypothesis is that it will lower the antibiotic prescription rate

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Key information

Conditions

Procalcitonin Bacteremia Bacterial Infection Bacterial Infections Bacterial Infections and Mycoses Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Fever Without Source Infections Inflammation Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome Urinary Tract Infections Urogenital Diseases Urologic Diseases

Age range

1 month–36 month

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Sainte-Justine Emergency Department

Montreal, Quebec, H3T1L7, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children 1-36 months
  • With rectal temperature >38.0 C
  • And no identified source of infection after history and physical examination

Exclusion criteria

  • acquired or congenital immunodeficiency

Treatment and study plan

Procalcitonin dosage PCT-Q test (Brahms, Germany)

Other

Procalcitonin result available to the attending physician

Other names: PCT-Q test (Brahms, Germany)

Primary outcomes

  1. Difference in prescription of antibiotics between the two groups, excluding those treated for a bacterial infection identified by the ED investigations

Secondary outcomes

  1. Difference in hospitalization rate between the two groups (excluding those hospitalized for an identified infection)

  2. Procalcitonin sensitivity and specificity

Sponsors and collaborators

Lead sponsor

St. Justine's Hospital

Other

Registry information

Official study title

The Impact of Procalcitonin on the Management of Children Aged 1 to 36 Month Presenting With a Fever Without a Source

Important dates

Study start
2006
Primary completion
2007
Study completion
2008
First posted
Jun 6, 2008
Registry last updated
Jun 6, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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