Impact of Periodontal Treatment on NT-proBNP Levels

In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 6-months follow-up, the post-treatment clinical and serum parameters in patients with periodontitis, treated by either Intensive scaling and root planing (SRP) treatment versus conventional oral hygiene treatment on serum CRP and NT-proBNP levels.

The null hypothesis to invalidate was that there were no variations, in relation to clinical and serum CRP and NT-proBNP.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

35 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Catania

Catania, CT, 95124, Italy

About this study

This trial was conducted in accordance with the World Medical Association's Declaration of Helsinki of 1975, and reviewed in 2016. The local ethical committee approved the study protocol and each patient was carefully informed about the possible inherent risks of the study and provided their informed written consent.

Subjects with a diagnosis of periodontitis were enrolled in this clinical trial. The inclusion criteria were: 1) good condition of general health, 2) a minimum of 2 teeth for each quadrant with a Pocket Depth (PD) ranging from 4-6 mm, 3) no involvement of the furcation, 4) a minimum of a six teeth per quadrant, respectively. The exclusion criteria were: 1) periodontal therapy during the last 12 months, 2) assumption of antibiotics during the last 6 months, 3) pregnancy, 4) any systemic condition which might affect the effects of the study treatment, 5) previous or current radiation or immunosuppressive therapies, 5) use of mouthwash containing antimicrobials during the previous 3 months, 6) no use of hormonal contraceptives, 7) medication by anti-inflammatory and immunosuppressive drugs, 8) previous history of hard-drinking, 9) smoking, 10) class II and III tooth mobility. Patients randomly undergo to full mouth SRP (test group) or oral hygiene treatment (control group)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

good condition of general health
a minimum of 2 teeth for each quadrant with
Pocket Depth (PD) ranging from 4-6 mm
no involvement of the furcation
a minimum of a six teeth per quadrant, respectively

Exclusion criteria

periodontal therapy during the last 12 months
assumption of antibiotics during the last 6 months
pregnancy
any systemic condition which might affect the effects of the study treatment
previous or current radiation or immunosuppressive therapies
use of mouthwash containing antimicrobials during the previous 3 months
no use of hormonal contraceptives
medication by anti-inflammatory and immunosuppressive drugs
previous history of hard drinking
smoking
class II and III tooth mobility

Treatment and study plan

Evaluation of serum CRP and NT-proBNP

Diagnostic Test

All patients were evaluated to 6-months post-treatment reduction of serum CRP and NT-proBNP

Primary outcomes

Change of Clinical Attachment Level

Time frame: 6-months

Change of periodontal Clinical Attachment Level

Sponsors and collaborators

Lead sponsor

University of Catania

Other

Registry information

Official study title

Impact of Non Surgical Periodontal Treatment on Serum NT-proBNP Levels

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Dec 30, 2021
Registry last updated: Jan 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed