Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

Participants in this study will undergo an in-person screening session where the study will be explained in detail and participants will answer questions and provide a breath sample. During the screening session, participants will also be asked to complete surveys. Eligible participants will then complete the training procedures during which they will select an e-cigarette device to use for future preference sessions. During the 4 preference sessions, participants will sample puffs from an e-cigarette and regular cigarette and answer questions about their experience with each. They will also complete a task during which they can choose to earn puffs from the e-cigarette or regular cigarette, or choose to not take any puffs. The 4 sessions will be the same except that a different combination of e-cigarette and regular cigarette is used at each session.

Inclusion criteria

• Legal age to purchase tobacco products;
• Regular user of EC and CC;
• Owns the e-cigarette device used most often;
• Agrees to abstain from using all tobacco products for 12 hours prior to each experimental session;
• Self-reporting tobacco flavored e-liquid is preferred or usual flavor e-liquid

Exclusion criteria

• Unstable medical conditions as determined by the licensed medical professional;
• Unstable psychiatric conditions as determined by the licensed medical professional or PI;
• Currently pregnant, breastfeeding, trying to become pregnant or unwilling to agree to use adequate protection to avoid pregnancy;
• Serious quit attempt of either or both products in the past 3 months resulting in >30 days of abstinence;
• Currently using nicotine replacement therapy or other pharmacotherapies as cessation aide;
• Plans to quit use of either EC or CC, or all tobacco products in the next 45 days;
• Self-reporting nicotine-free, CBD, or THC liquid is preferred or usual e-liquid;
• Vital signs outside of the following range (participants failing for vital signs will be allowed to re-screen once):

• Systolic blood pressure (BP) greater than or equal to 160 mm/hg
• Diastolic BP greater than or equal to 100 mm/hg
• Heart rate greater than or equal to 115 bpm;
• Allergy to propylene glycol or vegetable glycerin;
• Previous adverse reaction when using vaping device or e-liquid;
• Current or recent alcohol or drug abuse problems;
• Previous use of SPECTRUM or other reduced nicotine content cigarettes in past 3 months;
• Literate and able to independently complete and comprehend the consent form and other written study materials and measures.