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NCT Number: NCT07268196

Impact of Liver Transplantation on Sexual Life and Function

Liver Transplantation (LT) is a lifesaving intervention with around 90% of recipients currently surviving the first postoperative year and subsequent life expectancy now exceeding 20 years. After the post-operative recovery period, however, LT recipients become more and more confronted with the challenges of re-engagement with life after transplantation, a need to reach a new stability, reestablish function in everyday life, reconnect with valued roles, regain independence, and resume work Sexual function is a very important parameter in the evaluation of Quality of Life (QoL), as it has been shown that sexual dysfunction in transplant patients is associated with increased depression and decreased QoL. There are several studies in the relevant literature supporting the recovery of sexual function in patients after liver transplantation. It has been found that recovery was observed in erectile dysfunction in male patients 6 months after liver transplantation.

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Key information

Conditions

Chronic Liver Disease and Cirrhosis Fibrosis Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

Male

Study type

Observational

Primary location

ILBS

New Delhi, National Capital Territory of Delhi, 110070, India

Location status: Recruiting

Location contact

Dr. Rajagopalan G, DNB

CONTACT

[email protected]

8220408324

About this study

Liver Transplantation (LT) is a lifesaving intervention with around 90% of recipients currently surviving the first postoperative year and subsequent life expectancy now exceeding 20 years. After the post-operative recovery period, however, LT recipients become more and more confronted with the challenges of re-engagement with life after transplantation, a need to reach a new stability, reestablish function in everyday life, reconnect with valued roles, regain independence, and resume work Sexual function is a very important parameter in the evaluation of Quality of Life (QoL), as it has been shown that sexual dysfunction in transplant patients is associated with increased depression and decreased QoL. There are several studies in the relevant literature supporting the recovery of sexual function in patients after liver transplantation. It has been found that recovery was observed in erectile dysfunction in male patients 6 months after LT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Married male Patients.
  • Decompensated Chronic Liver Disease awaiting elective liver transplantation.
  • Post Liver Transplant patients with stable graft function.

Exclusion criteria

  • Negative consent.
  • Patients with ongoing medical and surgical issues (biliary complications, graft complication etc.).
  • Acute on Chronic Liver Failure and Acute Liver Failure patients.

Treatment and study plan

No treatment

Other

This is an Observational Study

Primary outcomes

  1. Evaluation of sexual function by questionnaire method

    Time frame: pre transplant, 3,6,12 months

    Arizona Sexual Experience Scale (ASEX) scores for sexual dysfunction, ASEX scores are 5 point questionnaire with scores given for each question from 1-6. Total scores More than or equal to 19 indicate sexual dysfunction (higher the scores greater the sexual dysfunction).

  2. Evaluation of erectile dysfunction using questionnaire method

    Time frame: pre transplant, 3,6,12 months

    International Index for Erectile Function - 5 (IIEF-5) scores for erectile dysfunction IIEF 5 scores are also a 5 point questionnaire with score ranging 0-6 for each question. Total scores less than 15 indicate mild to moderate erectile dusfunction and scores less than 11 indicate moderate erectile dysfunction (lower the scores higher the erectile dysfunction)

Secondary outcomes

  1. Correlation between testosterone and Meld Na scores

    Time frame: pre transplant, 3,6,12 months

    Testosterone measured in ng/ml. Less than 2.84 ng/ml is considered as hypogonadism

  2. Sarcopenia implication in recovery of sexual function.

    Time frame: pre transplant, 3,6,12 months

    Sarcopenia measured by third lumbar vertebra Skeletal muscle index. Values less than 52 indicates sarcopenia

Study contacts

Contact information is provided by the study sponsor or research team.

Dr. Rajagopalan G, DNB

CONTACT

[email protected]

8220408324

Sponsors and collaborators

Lead sponsor

Institute of Liver and Biliary Sciences, India

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 5, 2025
Registry last updated
Dec 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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