Impact of Immunotherapy on Vestibular Function, The Mayo Clinic Arizona Experience

Primary outcomes

1. Change in clinically significant vestibulopathy - vestibular function

   Time frame: Baseline, 3 months, 6 months, 12 months

   Assessed using standard vestibular function testing. Results will be aggregated to determine overall vestibular function. Results from baseline (prior to initiating immunotherapy) will be compared to results at 3, 6, and 12 months.

2. Change in clinically significant vestibulopathy - hearing level

   Time frame: Baseline,12 months

   Assessed using Pure Tone Audiometry, a standard hearing test. Any change from baseline (prior to initiating immunotherapy) to 12 months will be reported.

3. Oscillopsia Severity Questionnaire (OSQ)

   Time frame: Baseline, 3 months, 6 months, 12 months

   The OSQ consists of 9 questions to assess visual environment sensation (episodes of oscillopsia). Questions are answered on a 5-point scale: always, often, sometimes, seldom, never. The OSQ is scored by calculating a mean item score, which results in a total score ranging from 1 to 5. A score of 3 or higher indicates moderate to extreme oscillopsia severity.