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NCT Number: NCT06497855

Impact of Estimated Concentration of Propofol on Implicit Memory Formation

Implicit memory formation and learning during general anaesthesia is a still debated question and no anesthetic regimen (ie intravenous anaesthesia vs inhalatory one) nor analgesic regimen (i.e. low or high opioids usage) has been identified for prevention.

With this study the investigators aim to investigate if, during Total Intravenous Anaesthesia with Target Controlled Infusion (TIVA-TCI) different concentrations of Propofol at loss of responsiveness, maintenance and return of responsiveness can have a role in implicit memory formation.

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Key information

Conditions

General Anaesthesia Implicit Memory

Age range

18 year–90 year

Sex eligibility

Female

Study type

Observational

Primary location

About this study

Implicit memory formation and learning during general anaesthesia is a still debated question and no anesthetic regimen (ie intravenous anaesthesia vs inhalatory one) nor analgesic regimen (i.e. low or high opioids usage) has been identified for prevention.

With this study the investigators aim to investigate if, during Total Intravenous Anaesthesia with Target Controlled Infusion (TIVA-TCI) different concentrations of Propofol at loss of responsiveness (CeP RoR), maintenance (CePMA) and return of responSiveness (CeP RoR) can have a role in implicit memory formation.

20 most common italiaN words will be continuously presented to the anaesthetized patients from Loss of responsiveness to end of surgery.

CeP RoR, MA and LoR, as well as patient state index (PSi) from Sedline monitor for hypnosis level monitoring will be recorded.

Within 24 hours, a trained psychologist will be present the patients the Word Steam Recognition Test, Free Recall and Force Choice recognition task to asses the presence of implicit memory formation. A second group, who did not hear the words, will be investigated to assess the role of chance in the above-mentioned test.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • General anaesthesia with TIVA-TCI

Exclusion criteria

  • ASA > III
  • Benzodiazepines premedication
  • Neurological/Psychiatric disease

Treatment and study plan

Primary outcomes

  1. The role of Propofol Concentration at the loss of responsiveness on Implicit Memory formation

    Time frame: CeP will be recorded at Loss of responsiveness. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.

    CeP at LOR will be compared between patients who exhibit or not implicit memory formation.

  2. The role of Propofol Concentration at the maintenance of anaesthesia on Implicit Memory formation

    Time frame: CeP will be recorded during anaesthesia maintenance. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.

    CeP at anaesthesia maintenance will be compared between patients who exhibit or not implicit memory formation.

  3. The role of Propofol Concentration at the return of responsiveness on Implicit Memory formation

    Time frame: CeP will be recorded at Return of responsiveness. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.

    CeP at ROR will be compared between patients who exhibit or not implicit memory formation.

Sponsors and collaborators

Lead sponsor

University of Padova

Other

Registry information

Official study title

Impact of Target Controlled Infusion Estimated Concentration of Propofol on Implicit Memory Formation During Propofol-Remifentanil General Anaesthesia

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 12, 2024
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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